碳酸二(2-甲氧基乙基)酯 | 626-84-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 中文名称: 碳酸二(2-甲氧基乙基)酯
• 英文名称: bis(2-methoxyethyl)carbonate
• 英文别名: di(2-methoxyethyl) carbonate；dimethoxyethyl carbonate；carbonic acid bis-(2-methoxy-ethyl ester)；Kohlensaeure-bis-(2-methoxy-aethylester)；Bis-(2-methoxy-aethyl)-carbonat；Methylcellosolve-carbonat；Bis(2-methoxyethyl) carbonate
• CAS: 626-84-6
• 化学式: C₇H₁₄O₅
• 分子量: 178.185
• InChiKey: STLGQBDVSTWGIP-UHFFFAOYSA-N

物化性质

• 沸点：
  231°C (estimate)
• 密度：
  1.0988

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  碳酸二(2-甲氧基乙基)酯 、 2,4-二氨基甲苯 在 甲氧基乙醇钠 作用下， 以 乙二醇甲醚 为溶剂， 反应 24.0h， 生成 N,N'-Bis(2-methoxyethoxycarbonyl)-4-methyl-1,3-phenylenediamine
  参考文献：
  名称：

  METHOD FOR PRODUCING URETHANES COMPOSED OF DI-FUNCTIONAL AROMATIC AMINES AND DIALKYL CARBONATES

  摘要：

  一种通过将芳香族二胺与二烷基碳酸酯反应制备脲的方法，其中有机二烷基碳酸酯的烷基基团包含2-18个碳原子和一个或多个杂原子，并在催化剂存在下进行反应。

  公开号：

  US20110137067A1
• 作为产物：
  描述：

  乙二醇甲醚 、 碳酸二甲酯 在 sodium methylate 作用下， 以29%的产率得到碳酸二(2-甲氧基乙基)酯
  参考文献：
  名称：

  Vanadocene and niobocene dihalides containing electron-withdrawing substituents in the cyclopentadienyl rings: Synthesis, characterization and cytotoxicity

  摘要：

  The first example of the group V metallocene dihalides substituted in the cyclopentadienyl rings with electron-withdrawing substituents is reported. This study includes synthesis and spectroscopic characterization of the series of vanadocene and niobocene compounds functionalized in the cyclopentadienyl rings with the ester groups. Structures of (eta(5)-C5H4COOPh)(2)VCl2, (eta(5)-C5H4COOMe)(2)VBr2 center dot CH2Cl2, (eta(5)-C5H4-COOPh)(2)NbCl2, (eta(5)-C5H4COOMe)(2)NbBr2 and (eta(5)-C5H4COOEt)(2)NbBr2 were determined by X-ray diffraction analysis. Cytotoxic activity toward human leukemia cells MOLT-4 was established in vitro for all newly prepared metallocene compounds. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.03.018

文献信息

• [EN] CANNABINOID DERIVATIVES<br/>[FR] DÉRIVÉS CANNABINOÏDES
  申请人：CANOPY GROWTH CORP

  公开号：WO2021113958A1

  公开（公告）日：2021-06-17

  This disclosure relates generally to cannabinoid derivatives, pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives.

  这份公开文件通常涉及大麻素衍生物、包含它们的药物组合物以及使用大麻素衍生物的方法。
• [EN] FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS<br/>[FR] COMPOSÉS TRICYCLIQUES FUSIONNÉS DE PYRIDAZINONE UTILES POUR TRAITER DES INFECTIONS À ORTHOMYXOVIRUS
  申请人：NOVARTIS AG

  公开号：WO2018042303A1

  公开（公告）日：2018-03-08

  The invention provides compounds of Formula (I): (I) as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

  该发明提供了如下式（I）的化合物：（I），以及包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗某些病毒性疾病，包括流感的方法。
• ISOCYANATE PRODUCTION PROCESS
  申请人：Shinohata Masaaki

  公开号：US20110092731A1

  公开（公告）日：2011-04-21

  An object of the present invention is to provide a process that enables isocyanate to be produced stably over a long period of time and at high yield without encountering problems of the prior art during production of isocyanate without using phosgene. The present invention discloses a process for producing an isocyanate by subjecting a carbamic acid ester to a thermal decomposition reaction, including the steps of: recovering a low boiling point component in a form of a gaseous phase component from a thermal decomposition reaction vessel in which the thermal decomposition reaction is carried out; recovering a liquid phase component containing a carbamic acid ester from a bottom of the thermal decomposition reaction vessel; and supplying all or a portion of the liquid phase component to an upper portion of the thermal decomposition reaction vessel.

  本发明的一个目的是提供一种能够在长时间内稳定地高产且不使用光气的情况下生产异氰酸酯的方法，而不会遇到先前生产异氰酸酯时的问题。本发明公开了一种通过将氨基甲酸酯经受热分解反应来生产异氰酸酯的方法，包括以下步骤：从进行热分解反应的反应釜中回收形成气相组分的低沸点组分；从热分解反应釜底部回收含有氨基甲酸酯的液相组分；并将全部或部分液相组分供给至热分解反应釜的上部。
• PROCESS FOR PRODUCING ISOCYANATES USING DIARYL CARBONATE
  申请人：Shinohata Masaaki

  公开号：US20110054211A1

  公开（公告）日：2011-03-03

  An object of the present invention is to provide a process that enables isocyanate to be produced stably over a long period of time and at high yield without encountering problems of the prior art during production of isocyanate without using phosgene. The present invention provides an isocyanate production process including the steps of: obtaining a reaction mixture containing an aryl carbamate having an aryl group originating in a diaryl carbonate, an aromatic hydroxy compound originating in a diaryl carbonate, and a diaryl carbonate, by reacting a diaryl carbonate and an amine compound in the presence of a reaction solvent in the form of an aromatic hydroxy compound; transferring the reaction mixture to a thermal decomposition reaction vessel; and obtaining isocyanate by applying the aryl carbamate to a thermal decomposition reaction, wherein the reaction vessel in which the reaction between the diaryl carbonate and the amine compound is carried out and the thermal decomposition reaction vessel for the aryl carbamate are different.

  本发明的一个目的是提供一种能够在生产异氰酸酯时在长时间内稳定地且高产率地生产异氰酸酯的方法，而不使用光气时遇到先前技术问题的方法。本发明提供了一种异氰酸酯生产方法，包括以下步骤：通过在反应溶剂形式的芳香羟基化合物存在下，通过反应二芳基碳酸酯和胺化合物得到含有源自二芳基碳酸酯的芳基碳酸酯、源自二芳基碳酸酯的芳香羟基化合物和二芳基碳酸酯的反应混合物；将反应混合物转移至热分解反应容器；通过将芳基碳酸酯应用于热分解反应来获得异氰酸酯，其中进行二芳基碳酸酯和胺化合物之间的反应的反应容器和用于芳基碳酸酯的热分解反应的反应容器是不同的。
• [EN] PYRROLE DERIVATIVES AS ACC INHIBITORS<br/>[FR] DÉRIVÉS DE PYRROLE UTILISÉS EN TANT QU'INHIBITEURS D'ACC
  申请人：ALMIRALL SA

  公开号：WO2019115405A1

  公开（公告）日：2019-06-20

  Novel pyrrole derivatives of Formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Acetyl- CoA carboxylase (ACC).

  公开了式（I）的新吡咯衍生物；以及它们的制备方法，包括它们的药物组合物以及它们作为乙酰辅酶A羧化酶（ACC）抑制剂在治疗中的用途。

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