3'-hydroxy-6'-methyl-spiro[phthalan-1,9'-xanthen]-3-one | 100733-03-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3'-hydroxy-6'-methyl-spiro[phthalan-1,9'-xanthen]-3-one
• 英文别名: 3'-Hydroxy-6'-methyl-spiro[phthalan-1,9'-xanthen]-3-on；3'-Hydroxy-6'-methylspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 100733-03-7
• 化学式: C₂₁H₁₄O₄
• 分子量: 330.34
• InChiKey: DOXUDNIJURDOFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  荧光素 在 sodium hydroxide 、 四氯化锡 作用下， 生成 3'-hydroxy-6'-methyl-spiro[phthalan-1,9'-xanthen]-3-one
  参考文献：
  名称：

  Ghatak; Dutt, Journal of the Indian Chemical Society, 1929, vol. 6, p. 468

  摘要：

  DOI：

文献信息

• [EN] SELECTIVE ARYLATION OF DICHALCOGENIDES IN BIOMOLECULES<br/>[FR] ARYLATION SÉLECTIVE DE DICHALCOGÉNIDES DANS DES BIOMOLÉCULES
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2016205798A1

  公开（公告）日：2016-12-22

  Disclosed are chemical transformations for the conjugation of unprotected peptide biomolecules. The processes feature several significant advantages over existing methods of peptide modification, including specificity towards selenocysteine over other nucleophiles (e.g., amines, hydroxyls), excellent functional group tolerance, and mild reaction conditions.

  本发明涉及用于结合未受保护的肽生物分子的化学转化方法。该过程相对于现有的肽修饰方法具有几个显著的优势，包括对硒蛋白氨基酸的特异性而不影响其他亲核物（例如氨基、羟基），良好的官能团耐受性和温和的反应条件。
• FLUORESCENT SCHIFF BASE CONJUGATE CU(II) CHEMOSENSORS AND METHODS THEREOF
  申请人：King Fahd University Of Petroleum And Minerals

  公开号：US20170276607A1

  公开（公告）日：2017-09-28

  Fluorescent Schiff base compounds comprising a xanthene dye based moiety and an alkyl imidazole moiety. Methods of assessing these fluorescent Schiff base compounds as fluorescent probes for metal ions in Cu 2+ chemosensing applications, methods of preparing the fluorescent Schiff base compounds and methods of detecting Cu 2+ ions with the same are also provided.

  本发明涉及荧光席夫碱化合物，包括基于黄色素染料的部分和烷基咪唑部分。提供了将这些荧光席夫碱化合物作为铜离子荧光探针在Cu2 +化学传感应用中评估的方法，制备荧光席夫碱化合物的方法以及检测Cu2 +离子的方法。
• OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE
  申请人：CORRY Schuyler Boon

  公开号：US20090047692A1

  公开（公告）日：2009-02-19

  The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactmase or instructions for using the components in an assay.

  本发明涉及一种酶底物化合物，经过与该酶的反应后提供可检测的响应，例如光学可检测响应。特别是，这些化合物在检测样品中β-内酰胺酶的存在方面具有实用性。除了这些化合物，还揭示了一种分析样品中β-内酰胺酶存在的方法，例如，作为包括编码β-内酰胺酶的核酸序列的表达的指示器。还揭示了包括上述化合物和其他组分的试剂盒，例如细胞、抗体、β-内酰胺酶或使用这些组分进行检测的说明。
• THIOL DETECTION
  申请人：Strongin Robert Michael

  公开号：US20120276649A1

  公开（公告）日：2012-11-01

  Embodiments of compounds for selectively detecting a thiol are disclosed. In some embodiments, the compounds are bridged viologens, and the compounds are capable of reacting with homocysteine and/or glutathione in a buffered solution to produce a change in the solution's absorbance spectrum and/or emission spectrum. Also disclosed are embodiments of methods and kits for detecting homocysteine and/or glutathione with the disclosed bridged viologens.

  本发明揭示了用于选择性检测巯基的化合物实施例。在某些实施例中，这些化合物是桥联苯并咪唑化合物，它们能够与缓冲溶液中的同型半胱氨酸和/或谷胱甘肽发生反应，产生溶液吸收光谱和/或发射光谱的变化。本发明还揭示了使用上述桥联苯并咪唑化合物检测同型半胱氨酸和/或谷胱甘肽的方法和试剂盒实施例。
• LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES
  申请人：Versitech Limited

  公开号：EP2250177B1

  公开（公告）日：2014-06-18