2',4',5',7'-四氯-3',6'-二羟基螺[2-苯并呋喃-3,9'-氧杂蒽]-1-酮 | 2320-38-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 2',4',5',7'-四氯-3',6'-二羟基螺[2-苯并呋喃-3,9'-氧杂蒽]-1-酮
• 英文名称: 2',4',5',7'-tetrachloro-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one
• 英文别名: 2',4',5',7'-Tetrachlor-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-on；2',4',5',7'-tetrachloro-fluorescein；2',4',5',7'-Tetrachlorofluorescein；2',4',5',7'-tetrachloro-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 2320-38-9
• 化学式: C₂₀H₈Cl₄O₅
• 分子量: 470.093
• InChiKey: WBLLWHYYHNSTFH-UHFFFAOYSA-N

物化性质

• 熔点：
  296-305 °C(Solv: acetic acid (64-19-7))
• 沸点：
  647.4±55.0 °C(Predicted)
• 密度：
  1.87±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  29
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  荧光素 在 Oxone 、 sodium chloride 作用下， 反应 12.0h， 以22%的产率得到2',4',5'-trichloro-fluorescein
  参考文献：
  名称：

  PROCESS FOR SYNTHESIZING HALOGENATED DERIVATIVES OF FLUORESCEIN FOR USE IN THE PRODUCTION OF NON-VOLATILE MEMORY DEVICES

  摘要：

  该过程执行卤代衍生物的荧光素固相合成，包括将荧光素与卤化物MX反应，其中M为碱金属，X为卤素，并在高于或等于150°C的温度下使用Oxone®（2KHSO5.KHSO4.K2SO4）。一种结构使用从2′，4′，5′-三氯荧光素、2′，4′，5′，7′-四氯荧光素、4′，5′-二碘荧光素二乙酸酯和2′，4′，5′-三碘荧光素中选择的卤代衍生物作为非挥发性存储器件中的电致双稳材料。

  公开号：

  US20080061289A1

文献信息

• Drug delivery system for hydrophobic drugs
  申请人：QLT, Inc.

  公开号：EP1900357A2

  公开（公告）日：2008-03-19

  Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Such microaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions favoring the production of small aggregates for improved filter sterilization.

  本文介绍了由含有疏水性药物的微团聚体组成的组合物及其生产方法。这种微团聚体可包括胶束结构或其与脂质体的组合，并构成疏水性药物的有效递送载体。微团聚体的生产方法包括使用优选的脂质化合物和有利于生产小团聚体的加工条件，以提高过滤灭菌效果。
• Improved Topical Medicaments and Methods for Photodynamic Treatment of Disease
  申请人：Provectus Pharmatech, Inc.

  公开号：EP2020242A2

  公开（公告）日：2009-02-04

  New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs; the mouth and digestive tract and related organs; the urinary and reproductive tracts and related organs; the respiratory tract and related organs; various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery; and for treatment of a variety of conditions related to microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid or aerosol delivery vehicles.

  本文描述了用于治疗人类或动物组织的新型光动力局部应用药物及其某些医疗用途，其中此类药物的主要活性成分是卤代呫吨。卤代呫吨构成了一个强效光敏剂家族，当治疗部位受到可见光波长的照射时，卤代呫吨会被光激活。在优选的实施方案中，此类药物用于治疗影响皮肤和相关器官、口腔和消化道及相关器官、泌尿道和生殖道及相关器官、呼吸道及相关器官、各种其他内部或外部组织表面，如手术中暴露的组织表面的各种病症，以及治疗与微生物或寄生虫感染有关的各种病症。在另一个优选的实施方案中，这类药物以各种配方生产，包括液体、半固体或气溶胶给药载体。
• Biophotonic materials and uses thereof
  申请人：KLOX TECHNOLOGIES INC.

  公开号：US10130706B2

  公开（公告）日：2018-11-20

  The present disclosure provides topical biophotonic materials and methods useful in phototherapy. In particular, the topical biophotonic materials of the present disclosure include a cohesive matrix, and at least chromophore which can absorb and emit light from within the topical biphotonic material, wherein the topical biophotonic material is elastic. The topical biophotonic materials and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various other skin disorders.

  本公开提供了用于光疗的局部生物光子材料和方法。特别是，本公开的局部生物光子材料包括粘性基质，以及至少能从局部双光子材料内部吸收和发射光的发色团，其中局部生物光子材料具有弹性。本公开的外用生物光子材料和方法可用于促进伤口愈合和嫩肤，以及治疗痤疮和其他各种皮肤疾病。
• Phototherapy devices and methods
  申请人：KLOX Technologies Inc.

  公开号：US10687926B2

  公开（公告）日：2020-06-23

  The present disclosure relates to a phototherapy device that can deliver light to tissues to activate photoactive agents that have been applied to the tissues or that are included within a fiber optic tip member of the device which may be coupled to a light source using a sleeve. The present disclosure also relates to methods of phototherapy using the phototherapy device such as anti-bactericidal treatment, anti-fungal treatment, anti-parasitic treatment, anti-viral treatment.

  本公开涉及一种光疗装置，该装置可将光输送到组织，以激活涂抹在组织上的光活性剂，或包括在该装置的光纤尖端部件内的光活性剂，该装置可使用套管与光源耦合。本公开还涉及使用光疗装置进行光疗的方法，如抗菌治疗、抗真菌治疗、抗寄生虫治疗、抗病毒治疗。
• Tissue filler compositions and methods of use
  申请人：KLOX TECHNOLOGIES INC.

  公开号：US10772990B2

  公开（公告）日：2020-09-15

  The present disclosure relates to methods for stimulating collagen synthesis, cosmetic enhancement of soft tissue and/or inhibiting or treating scarring comprising administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium and a fluorophore; and illuminating the area with light having a wavelength which can be absorbed by the fluorophore.

  本公开涉及刺激胶原蛋白合成、软组织美容增强和/或抑制或治疗瘢痕的方法，包括向软组织内待治疗区域施用组合物，其中组合物包括组织填充介质和荧光团；以及用具有可被荧光团吸收的波长的光照射该区域。