7-(sulfooxy)ursodeoxycholic acid | 74723-14-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 7-(sulfooxy)ursodeoxycholic acid
• 英文别名: 3α-hydroxy-7β-sulfooxy-5β-cholane-24-oic acid；(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-sulfooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
• CAS: 74723-14-1
• 化学式: C₂₄H₄₀O₇S
• 分子量: 472.643
• InChiKey: DPVCTIYTPXYDMQ-UZVSRGJWSA-N

物化性质

• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  130
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  熊去氧胆酸 在 吡啶 、 三氧化硫吡啶 作用下， 反应 0.17h， 以4.1%的产率得到7-hydroxy-3-(sulfooxy)-(3α,5β,7β)-cholan-24-oic acid
  参考文献：
  名称：

  Bandiera, Tiziano; Albini, Franca Marione; Albini, Enrico, Synthetic Communications, 1987, vol. 17, # 9, p. 1111 - 1118

  摘要：

  DOI：

文献信息

• Composition and therapies for hyperlipidaemia-associated disorders
  申请人：——

  公开号：US20040009961A1

  公开（公告）日：2004-01-15

  The invention relates to pharmaceutical compositions comprising at least one fibrate and at least one bile acid, and to methods for the treatment of hyperlipidaemia or elevated liver function tests in a patient by administering at least one fibrate and at least one bile acid to the patient.

  本发明涉及包含至少一种纤维酸盐和至少一种胆汁酸的药物组合物，以及通过向患者施用至少一种纤维酸盐和至少一种胆汁酸来治疗患者高脂血症或肝功能检测升高的方法。
• EP1284723A4
  申请人：——

  公开号：EP1284723A4

  公开（公告）日：2004-06-30
• COMPOSITIONS AND THERAPIES FOR HYPERLIPIDAEMIA-ASSOCIATED DISORDERS
  申请人：Borody, Thomas, Julius

  公开号：EP1284723A1

  公开（公告）日：2003-02-26
• COMPOSITION AND THERAPIES FOR HYPERLIPIDAEMIA-ASSOCIATED DISORDERS
  申请人：BORODY THOMAS JULIUS

  公开号：US20080286354A1

  公开（公告）日：2008-11-20

  The invention relates to pharmaceutical compositions comprising at least one fibrate and at least one bile acid, and to methods for the treatment of hyperlipidaemia or elevated liver function tests in a patient by administering at least one fibrate and at least one bile acid to the patient.
• [EN] COMPOSITIONS AND THERAPIES FOR HYPERLIPIDAEMIA-ASSOCIATED DISORDERS<br/>[FR] COMPOSITIONS ET METHODES POUR TRAITER DES TROUBLES ASSOCIES A L'HYPERLIPIDEMIE
  申请人：BORODY THOMAS J

  公开号：WO2001080852A1

  公开（公告）日：2001-11-01

  The invention relates to pharmaceutical compositions comprising at least one fibrate and at least one bile acid, and to methods for the treatment of hyperlipidaemia or elevated liver function tests in a patient by administering at least one fibrate and at least one bile acid to the patient.