bis(2-(piperazin-1-yl)ethyl)amine | 107976-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: bis(2-(piperazin-1-yl)ethyl)amine
• 英文别名: 2-piperazin-1-yl-N-(2-piperazin-1-ylethyl)ethanamine
• CAS: 107976-34-1
• 化学式: C₁₂H₂₇N₅
• 分子量: 241.38
• InChiKey: GXXKZNABQGUBCX-UHFFFAOYSA-N

物化性质

• 沸点：
  360.0±10.0 °C(Predicted)
• 密度：
  0.995±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  42.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-氨乙基哌嗪 在 氢气 作用下， 155.0 ℃ 、5.62 MPa 条件下， 生成 bis(2-(piperazin-1-yl)ethyl)amine
  参考文献：
  名称：

  [EN] FORMATION OF HIGHER MOLECULAR WEIGHT CYCLIC POLYAMINE COMPOUNDS FROM CYCLIC POLYAMINE COMPOUNDS
  [FR] FORMATION DE COMPOSÉS POLYAMINE CYCLIQUE DE MASSE MOLÉCULAIRE SUPÉRIEURE À PARTIR DE COMPOSÉS POLYAMINE CYCLIQUE

  摘要：

  本发明提供了一种从较低分子量的环状多胺起始化合物经过转氨作用制备更高分子量的环状多胺的策略。这些更高分子量的环状多胺在结构上类似于较低分子量的环状多胺起始化合物。本发明中使用的反应物包括一个环状多胺组分，该组分至少包含两个胺基，这些胺基之间至少相隔一个二元碳原子间距，并且可以通过转氨作用形成更高分子量的环状多胺化合物。更高分子量的环状多胺至少有两个环状环通过含氮烃基团连接在一起。每个环状环都包含两个胺基，这些胺基之间相隔一个二元碳原子间距。

  公开号：

  WO2013101345A1

文献信息

• PRODUCTION METHOD FOR ETHYLENEAMINE MIXTURES
  申请人：Dahmen Kirsten

  公开号：US20100099872A1

  公开（公告）日：2010-04-22

  The invention relates to a process for preparing an ethylene amine mixture, which comprises hydrogenating an amino nitrile mixture comprising at least two α-amino nitriles in an amount of at least 5% by weight in each case in the presence of a catalyst and, if appropriate, a solvent.

  该发明涉及一种制备乙烯胺混合物的方法，包括在催化剂的存在下氢化氨基腈混合物，所述氨基腈混合物中至少含有两种α-氨基腈，每种至少占重量的5％，并且如有必要，还包括溶剂。
• [EN] PROCESS FOR MANUFACTURING CHAIN-EXTENDED HYDROXYETHYLETHYLENEAMINES, ETHYLENEAMINES, OR MIXTURES THEREOF<br/>[FR] PROCÉDÉ DE FABRICATION D'HYDROXYÉTHYLÉTHYLÈNEAMINES À CHAÎNE ÉTENDUE, D'ÉTHYLÈNEAMINES OU DE MÉLANGES DE CELLES-CI
  申请人：AKZO NOBEL CHEMICALS INT BV

  公开号：WO2018166938A1

  公开（公告）日：2018-09-20

  The invention pertains to a process for preparing hydroxyethylethyleneamines, ethyleneamines, or mixtures thereof, and/or ethylene urea derivatives thereof comprising the step of reacting diethanolamine with an amine-functional compound comprising at least two –NH-units of which at least one is selected from the group of primary amine groups and cyclic secondary amine groups, the amine-functional compound comprising at least one –NH-CH2-CH2-NH-unit wherein one or more -NH- CH2-CH2-NH-units in the amine-functional compound may be present in the form of cyclic ethylene urea moieties, piperazine moieties, or linear ethylene urea moieties, in the presence of a carbon oxide delivering agent, wherein -the molar ratio of amine-functional compound to diethanolamine is at least 0.2:1, and -the molar ratio of carbon oxide delivering agent to –NH-CH2-CH2-NH-units in the amine-functional compound is at least 0.1:1. The invention makes it possible to obtain higher hydroxyethylethyleneamines, ethyleneamines, or mixtures thereof, and/or ethylene urea derivatives thereof from diethanolamine, which is an attractive starting material.

  该发明涉及一种制备羟乙基乙烯胺、乙烯胺或二者的混合物，和/或其乙烯脲衍生物的过程，包括将二乙醇胺与一种含有至少两个-NH-基团的胺基化合物反应的步骤，其中至少一个选自一次胺基团和环状二次胺基团的组中，该胺基化合物包括至少一个-NH-CH2-CH2-NH-基团，其中该胺基化合物中的一个或多个-NH-CH2-CH2-NH-基团可以以环状乙烯脲基团、哌嗪基团或线性乙烯脲基团的形式存在，存在一种碳氧化物传递剂的情况下，其中-胺基化合物与二乙醇胺的摩尔比至少为0.2:1，和-碳氧化物传递剂与胺基化合物中的-NH-CH2-CH2-NH-基团的摩尔比至少为0.1:1。该发明使得从二乙醇胺中获得更高的羟乙基乙烯胺、乙烯胺或二者的混合物，和/或其乙烯脲衍生物成为可能，而二乙醇胺是一种有吸引力的起始原料。
• Intranasal cyclic peptide formulations
  申请人：——

  公开号：US20010038824A1

  公开（公告）日：2001-11-08

  The present invention relates to a nasally administrable composition of a physiologically active cyclic peptide and pharmaceutically acceptable salts thereof that is prepared by homogeneously dispersing a physiologically active cyclic peptide such as antifungal cyclic peptides (aerothricins, echinocandin analogs, pneumocandin analogs, and aureobacidines), antibacterial cyclic peptides (e.g. vancomycin, daptomycin), cyclosporin A, lanreotide, vapreotide, vasopressin antagonist (U.S. Pat. No. 5,095,003) and eptifibatide in unique carrier, i.e. a physiologically acceptable powdery or crystalline carrier containing a water insoluble polyvalent metal carrier, or organic carrier having a mean particle size of 20 to 500 &mgr;m, in the presence or absence of an absorption enhancer and by homogeneously adsorbing onto the carrier, and its use for therapeutic treatment of disease such as systemic fungal infections by intranasal administration. The composition can be nasally administered in powder form.

  本发明涉及一种鼻腔可给药的生理活性环肽及其药学上可接受的盐的组合物，该组合物通过将生理活性环肽（如抗真菌环肽（气菌素、伊曲康定类似物、肺孢子菌素类似物和金黄色细菌素）、抗菌环肽（如万古霉素、达托霉素）、环孢霉素A、兰雷罗肽、瓦普雷罗肽、抗利尿激素拮抗剂（美国专利号5,095,003）和依普利贝肽）均匀分散在独特的载体中制备而成，即含有水不溶性多价金属载体或平均粒径为20至500微米的有机载体的生理上可接受的粉状或结晶载体中，存在或不存在吸收增强剂，通过均匀吸附到载体上，并用于通过鼻内给药治疗疾病，如系统真菌感染。该组合物可以以粉剂形式鼻腔给药。
• AMINE ALKOXYLATE COMPOSITIONS AND THEIR USE AS LUBRICANT ADDITIVES
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：US20150232776A1

  公开（公告）日：2015-08-20

  Provided are compositions and their use as dispersant and/or detergent additives for lubricants. The compositions comprise an amine alkoxylate of the formula I: (I) wherein R 1 -R 7 , R 1 ′-R 7 ; x, x′, A, A′ and A″ are as defined herein.

  提供的是组合物及其作为润滑剂分散剂和/或清洁剂添加剂的用途。该组合物包括式I的胺烷氧基化物：（I）其中R1-R7，R1'-R7'，x，x'，A，A'和A''如本文中所定义。
• Stable, aqueous dispersions of polyurethane-ureas and coatings and films prepared therefrom
  申请人：BAYER AG

  公开号：EP0148970A2

  公开（公告）日：1985-07-24

  The present invention relates to a stable, aqueous dispersion of polyurethane-ureas wherein said polyurethane-ureas contain i) about 2 to 200 milliequivalents per 100 grams of polyurethane-urea of chemically incorporated anionic groups, and ii) up to about 15% by weight, based on the weight of the polyurethane-urea, of lateral and/or terminal hydrophilic chains containing ethylene oxide units, wherein the counterions of the anionic groups are a mixture of volatile and non-volatile cations in an equivalent ratio of about 1:10 to 10:1. The present invention is also directed to the coatings and films prepared from these dispersions.

  本发明涉及一种稳定的聚氨酯-尿素水分散体，其中所述聚氨酯-尿素包含 i) 每 100 克聚氨酯脲中含有约 2 至 200 毫当量的化学合成阴离子基团，以及 ii) 以聚氨酯脲重量为基准，含有环氧乙烷单元的侧亲水链和/或端亲水链的重量比高达约 15%，其中阴离子基团的反离子是挥发性和非挥发性阳离子的混合物，等效比例约为 1:10 至 10:1。 本发明还涉及用这些分散体制备的涂料和薄膜。