2,6-diamino-3,5-dicyano-thiopyran | 134836-45-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫吡喃类
• 英文名称: 2,6-diamino-3,5-dicyano-thiopyran
• 英文别名: 2,6-diamino-4H-thiopyran-3,5-dicarbonitrile
• CAS: 134836-45-6
• 化学式: C₇H₆N₄S
• mdl: MFCD00579892
• 分子量: 178.217
• InChiKey: HZTHPFYHJIYIFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,6-diamino-3,5-dicyano-thiopyran 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以91%的产率得到6-amino-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile
  参考文献：
  名称：

  Elnagdi, Mohamed Hilmy; Ghozlan, Said Ahmed Soliman; Abdelrazek, Fathy Mohamed, Journal of Chemical Research, Miniprint, 1991, # 5, p. 1021 - 1032

  摘要：

  DOI：
• 作为产物：
  描述：

  聚合甲醛 、 2-氰基硫代乙酰胺 、 丙二腈 在 哌啶 作用下， 以 乙醇 为溶剂， 以60%的产率得到2,6-diamino-3,5-dicyano-thiopyran
  参考文献：
  名称：

  Elnagdi, Mohamed Hilmy; Ghozlan, Said Ahmed Soliman; Abdelrazek, Fathy Mohamed, Journal of Chemical Research, Miniprint, 1991, # 5, p. 1021 - 1032

  摘要：

  DOI：

文献信息

• Adenosine receptor ligands and their use in the treatment of disease
  申请人：——

  公开号：US20010027196A1

  公开（公告）日：2001-10-04

  The invention relates to cyclic heteroaromatic compounds, containing at least one nitrogen atom, and to their use in the manufacture of medicaments for the treatment of diseases, related to adenosine receptor modulators, such as Alzheimer's disease, Parkinson's disease, neuroprotection, schizophrenia, anxiety, pain, respiration deficits, depression, asthma, allergic responses, hypoxia, ischaemia, seizure, substance abuse, sedation and they may be active as muscle relaxants, antipsychotics, anti epileptics, anticonvulsants and cardiaprotective agents.

  这项发明涉及含有至少一个氮原子的环状杂芳化合物，以及它们在制造用于治疗与腺苷受体调节剂相关的疾病的药物中的应用，如阿尔茨海默病、帕金森病、神经保护、精神分裂症、焦虑、疼痛、呼吸功能障碍、抑郁症、哮喘、过敏反应、缺氧、缺血、癫痫、物质滥用、镇静，它们可能作为肌肉松弛剂、抗精神病药、抗癫痫药、抗惊厥药和心脏保护剂而具有活性。
• INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF
  申请人：Cornell University

  公开号：US20150196546A1

  公开（公告）日：2015-07-16

  The invention is directed to a method of treating a cancer in an animal and a method of increasing DNA repair activity in an animal. The methods comprise administering to an animal in need thereof an effective amount of a small molecule substance that interferes with the activity of CUL4A, such as a 1,3-benzoxathiol-2-one compound, a pyridine thione compound, a 2,6-diamino-4-thiopyran-3,5-dicarbonitrile compound, or a 1,2,4-triazole-3-thiol compound.

  本发明涉及一种治疗动物癌症和增加动物DNA修复活性的方法。该方法包括向需要治疗的动物中投与有效量的干扰CUL4A活性的小分子物质，比如1,3-苯并噻吩-2-酮化合物、吡啶硫酮化合物、2,6-二氨基-4-硫代吡喃-3,5-二氰基化合物或1,2,4-三唑-3-硫醇化合物。
• Use of ubiquitin-proteasome system inhibitors for treatment of tumors associated with neurofibromatosis type-2
  申请人：BIOXCEL CORPORATION

  公开号：US10610563B2

  公开（公告）日：2020-04-07

  The invention discloses a method of treating, preventing or ameliorating tumor or symptoms resulting from defective neurofibromatosis type-2 gene in a subject by administering to the subject a therapeutically effective amount of a ubiquitin-proteasome system inhibitor which inhibits or slows the growth of neurofibromatosis type-2-deficient tumor or associated symptoms. The invention also includes methods of diagnosis and screening of patients for neurofibromatosis type-2 and mesothelioma.

  本发明公开了一种治疗、预防或改善受试者因2型神经纤维瘤病基因缺陷而导致的肿瘤或症状的方法，其方法是向受试者施用治疗有效量的泛素-蛋白酶体系统抑制剂，该抑制剂可抑制或减缓2型神经纤维瘤病基因缺陷肿瘤或相关症状的生长。本发明还包括诊断和筛查2型神经纤维瘤病和间皮瘤患者的方法。
• Inhibitors of CRL4 ubiquitin ligase and uses thereof
  申请人：Cornell University

  公开号：US10617683B2

  公开（公告）日：2020-04-14

  The invention is directed to a method of treating a cancer in an animal and a method of increasing DNA repair activity in an animal. The methods comprise administering to an animal in need thereof an effective amount of a small molecule substance that interferes with the activity of CUL4A, such as a 1,3-benzoxathiol-2-one compound, a pyridine thione compound, a 2,6-diamino-4-thiopyran-3,5-dicarbonitrile compound, or a 1,2,4-triazole-3-thiol compound.

  本发明涉及一种治疗动物癌症的方法和一种提高动物 DNA 修复活性的方法。这些方法包括向有需要的动物施用有效量的干扰CUL4A活性的小分子物质，如1,3-苯并氧硫醇-2-酮化合物、吡啶硫酮化合物、2,6-二氨基-4-噻喃-3,5-二甲腈化合物或1,2,4-三唑-3-硫醇化合物。
• Pyrolysis and photolysis processes of pyran and thiopyran derivatives
  作者：A. A. Atalla、A. M. Hussein、M. Z. A. Badr

  DOI：10.1007/bf00807636

  日期：1997.1

  Pyrolysis and photolysis of 2-amino-3,5-dicyano-6-phenyl-4H-pyran (1) afford HNCO, acrylonitrile, cinnamonitrile, and 2-hydroxy-3,5-dicyano-6-phenylpyridine. Pyrolysis of 2-carboxyimino-3,5-dicyano-6-phenyI-4H-pyran (2) gives HCN, acrylonitrile, cinnamonitrile and 2-hydroxy-3,5-dicyano-6-phenylpyridine. Furthermore, both pyrolysis and photolysis of 2,6-diamino-3,5-dicyanothiopyran (3a) gives rise to HNCS, acrylonitrile and 6-amino-3,5-dicyano-6-mercaptopyridin, Moreover, comparative studies of pyrolysis and photolysis of 2,6-dicyano-4-arylthiopyran derivatives 3b-d revealed similar results. The similarity of products obtained from pyrolysis and photolysis and the mechanistic implications of these data are discussed.