1-(1-phenylcyclohexyl)-4-piperidone | 77179-42-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(1-phenylcyclohexyl)-4-piperidone
• 英文别名: 1-(1-phenylcyclohexyl)piperidin-4-one；(1-phenylcyclohexyl)-4-piperidone
• CAS: 77179-42-1
• 化学式: C₁₇H₂₃NO
• 分子量: 257.376
• InChiKey: WECCNDJWFKQPSD-UHFFFAOYSA-N

物化性质

• 熔点：
  85-86 °C
• 沸点：
  391.2±22.0 °C(Predicted)
• 密度：
  1.087±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(1-phenylcyclohexyl)-4-piperidone 在 三甲基氯硅烷 、 水 作用下， 以 乙醚 为溶剂， 生成 1-(1-phenylcyclohexyl)piperidin-4-one;hydrochloride
  参考文献：
  名称：

  Substituted 4-phenyl-1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridine

  摘要：

  替代4-苯基-1-(1-苯基环己基)-1,2,3,6-四氢吡啶（化合物），其生产方法，含有该化合物的药物组合物，以及使用该药物组合物治疗疼痛和其他疾病的方法。

  公开号：

  US20030225116A1
• 作为产物：
  描述：

  8-(1-Phenylcyclohexyl)-1,4-dioxa-8-azaspiro[4.5]decane 在 盐酸 、 水 、 氨 作用下， 以 水 为溶剂， 反应 12.0h， 以60%的产率得到1-(1-phenylcyclohexyl)-4-piperidone
  参考文献：
  名称：

  Substituted 4-phenyl-1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridine

  摘要：

  替代4-苯基-1-(1-苯基环己基)-1,2,3,6-四氢吡啶（化合物），其生产方法，含有该化合物的药物组合物，以及使用该药物组合物治疗疼痛和其他疾病的方法。

  公开号：

  US20030225116A1

文献信息

• Phencyclidine and phencyclidine metabolites assay, tracers, immunogens,
  申请人：Abbott Laboratories

  公开号：US05155212A1

  公开（公告）日：1992-10-13

  The present invention is directed to a fluorescence polarization assay for phencyclidine and phencyclidine derivatives, to the various components needed for preparting and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for making them, and a reagent kit containing them. The tracers and the immunogens are made from substituted phencyclidine compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.

  本发明涉及一种用于苯环丙胺和苯环丙胺衍生物的荧光偏振测定的方法，以及制备和实施该测定所需的各种组分，以及制备这些组分的方法。具体包括揭示了示踪剂、免疫原和抗体，以及制备它们的方法，以及包含它们的试剂盒。示踪剂和免疫原是由取代苯环丙胺化合物制备的。示踪剂中包含荧光素基团，而多肽（氨基酸）是免疫原的一部分。该测定是通过测量已通过含有抗血清和示踪剂的样品的偏振保持程度的平面偏振光来进行的。
• New analgesic drugs derived from phencyclidine
  作者：Yossef Itzhak、Asher Kalir、Ben Avi Weissman、Sasson Cohen

  DOI：10.1021/jm00137a004

  日期：1981.5

  1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol (10) and its propionate (11), and 1-(1-phenylcyclohexyl)-4-phenylpiperidine (13) were prepared and characterized. The new compounds, which are derived from phencyclidine, exerted analgesic activity in mice. The most potent is 10, which is twice as active as morphine. The antinociceptive activity of 10, 11, and 13 could be well correlated with their potency in the mouse

  1-（1-苯基环己基）-4-哌啶醇（3），1-（1-苯基环己基）-4-苯基-4-哌啶醇（10）及其丙酸酯（11）和1-（1-苯基环己基）的几种酯制备并表征了）-4-苯基哌啶（13）。衍生自苯环利定的新化合物在小鼠中发挥镇痛作用。最有效的是10，活性是吗啡的两倍。10、11和13的抗伤害感受活性可能与它们在小鼠输精管生物测定中的功效密切相关，并且纳洛酮可完全逆转两者。
• Phencyclidine and phencyclidine metabolites assay, tracers, immunogens
  申请人：Abbott Laboratories

  公开号：US05124457A1

  公开（公告）日：1992-06-23

  The present invention is directed to a fluorescence polarization assay for phencyclidine and phencyclidine derivatives, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for making them. The tracers and the immunogens are made from substituted phencyclidine compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.

  本发明涉及一种用于苯环丙胺和苯环丙胺衍生物的荧光偏振测定的方法，涉及用于准备和执行此类测定所需的各种组分，以及制备这些组分的方法。具体地，公开了示踪剂、免疫原和抗体，以及制备它们的方法。示踪剂和免疫原由取代苯环丙胺化合物制成。示踪剂中包含荧光基团，而多肽（氨基酸）构成免疫原的一部分。该测定通过测量已通过含有抗血清和示踪剂的样品的偏振保留度的平面偏振光的程度来进行。
• Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit
  申请人：ABBOTT LABORATORIES

  公开号：EP0459387A2

  公开（公告）日：1991-12-04

  The present invention is directed to a fluorescence polarization assay for phencyclidine and phencyclidine derivatives, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for making them, and a reagent kit containing them. The tracers and the immunogens are made from substituted phencyclidine compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.

  本发明涉及苯环利定和苯环利定衍生物的荧光偏振测定法、制备和进行这种测定法所需的各种成分以及制造这些成分的方法。具体而言，本发明公开了示踪剂、免疫原和抗体，以及制造它们的方法和含有它们的试剂盒。示踪剂和免疫原由取代的苯环利定化合物制成。示踪剂中含有荧光素分子，而免疫原中含有聚氨基酸分子。检测方法是测量通过含有抗血清和示踪剂的样品的平面偏振光的偏振保留程度。
• ITZHAK, Y.;KALIR, A.;WEISSMAN, B. A.;COHEN, S., J. MED. CHEM., 1981, 24, N 5, 496-499
  作者：ITZHAK, Y.、KALIR, A.、WEISSMAN, B. A.、COHEN, S.

  DOI：——

  日期：——