N-Butyl-N'-ethylurea | 10310-60-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: N-Butyl-N'-ethylurea
• 英文别名: N-Aethyl-N'-butyl-harnstoff；N-Aethyl-N'-n-butyl-harnstoff；N-Ethyl-N'-butylharnstoff；N-ethyl-N'-butyl-urea；1-Butyl-3-ethylurea
• CAS: 10310-60-8
• 化学式: C₇H₁₆N₂O
• mdl: MFCD00091819
• 分子量: 144.217
• InChiKey: BFLWAUWLGJKDMJ-UHFFFAOYSA-N

物化性质

• 熔点：
  58-59 °C
• 沸点：
  280.8±9.0 °C(Predicted)
• 密度：
  0.907±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  N-Butyl-N'-ethylurea 、 氰乙酸 在 乙酸酐 作用下， 生成 3-ethyl-6-amino-1-butyl-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Some Alkyl Homologs of Theophylline

  摘要：

  DOI：

  10.1021/ja01097a032
• 作为产物：
  描述：

  硫酸二乙酯 以80%的产率得到N-Butyl-N'-ethylurea
  参考文献：
  名称：

  Process for the N-alkylation or ureas

  摘要：

  尿素的N-烷基化过程是通过在稀释剂中，在固体碱和相转移催化剂的存在下，将尿素与烷基化剂反应实现的。

  公开号：

  US05124451A1

文献信息

• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSÉS CHIMIQUES
  申请人：BORAGEN INC

  公开号：WO2021061823A1

  公开（公告）日：2021-04-01

  The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the disclosure have activity as Janus kinase (JAK) inhibitors and are useful in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described herein are methods of treating inflammation, auto-immune diseases, cancer, and other conditions susceptible to inhibition of JAK by administering a compound herein described.

  本公开描述了新颖化合物或其药用盐、含有它们的药物组合物以及它们的医药用途。本公开的化合物具有作为Janus激酶（JAK）抑制剂的活性，并且在治疗或控制炎症、自身免疫疾病、癌症以及其他需要调节JAK的紊乱和适应症方面是有用的。本文还描述了通过给予本文描述的化合物来治疗炎症、自身免疫疾病、癌症以及其他容易受到JAK抑制影响的疾病的方法。
• Synthesis and Application of a New Fluorous-Tagged Ammonia Equivalent
  作者：Simon D. Nielsen、Garrick Smith、Mikael Begtrup、Jesper L. Kristensen

  DOI：10.1002/chem.200903178

  日期：2010.4.19

  A novel fluorous‐tagged ammonia equivalent has been developed. It is based on a nitrogen–oxygen bond, which can be cleaved in a traceless manner by a molybdenum complex or samarium diiodide. The application in the synthesis of ureas, amides, sulfonamides, and carbamates is described. The scope of the fluorous NO linker is exemplified by the synthesis of itopride, a drug used for the treatment of functional

  已经开发出一种新型的含氟标签的氨当量。它基于氮-氧键，可以通过钼络合物或二碘化sa无痕地裂解。描述了在合成脲，酰胺，磺酰胺和氨基甲酸酯中的应用。氟氮原子连接基团的范围以伊托必利的合成为例，伊托必利是一种用于治疗功能性消化不良的药物。借助于氟纯化方法合成了伊托必利，并以良好的总收率和高纯度分离了产物。
• Trapping of Isocyanates with Benzotriazole in situ - Preparation of Carbamoyl Benzotriazoles as an Isocyanate Alternative via Curtius Rearrangement
  作者：Xiaoxia Wang、Zhiyun Zhong、Lichun Kong、Xiangming Zhu

  DOI：10.1055/s-0029-1217820

  日期：2009.9

  N-Aryl and N-alkenyl carbamoyl benzotriazoles were prepared in good to excellent yields from acyl azides and benzotri-azole via Curtius rearrangement, while N-alkylcarbamoyl benzotriazoles were formed from N-alkanoyl benzotriazoles and sodium azide in one pot. The carbamoyl benzotriazoles can be used as a stable isocyanate alternative, as has been demonstrated by its reaction with amines to synthesize

  N-芳基和N-烯基氨基甲酰基苯并三唑通过Curtius重排从酰基叠氮化物和苯并三唑以良好到优异的产率制备，而N-烷基氨基甲酰基苯并三唑由N-烷酰基苯并三唑和叠氮化钠在一锅中形成。氨基甲酰基苯并三唑可用作稳定的异氰酸酯替代物，正如其与胺反应以优异的产率合成脲所证明的那样。
• METHOD FOR PRODUCING FLUORINE-CONTAINING ACYLACETIC ACID DERIVATIVE, METHOD FOR PRODUCING FLUORINE-CONTAINING PYRAZOLECARBOXYLIC ACID ESTER DERIVATIVE, AND METHOD FOR PRODUCING FLUORINE-CONTAINING PYRAZOLECARBOXYLIC ACID DERIVATIVE
  申请人：Mitsui Chemicals Agro, Inc.

  公开号：EP2263999A1

  公开（公告）日：2010-12-22

  A halogenating agent is added to a mixture including a base, a fluoroalkylcarboxylic acid derivative and an acrylate derivative to produce a fluoroaclyacetic acid derivative represented by the following Formula (3): wherein Rf represents a fluorine containing alkyl group, R1 and R2 represent a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, an arylalkyl grou p or an acyl group, or together represent an atomic group that forms a 5- or 6-memb ered ring containing a nitrogen atom to which R1 and R2 are bonded; R3 represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, or an arylalkyl g roup; and R4 represents an alkyl group, a cycloalkyl group, an aryl group, or an aryl alkyl group.

  在包括碱、氟烷基羧酸衍生物和丙烯酸酯衍生物的混合物中加入卤化剂，生成由下式（3）表示的氟乙酸衍生物： 其中 Rf 代表含氟烷基，R1 和 R2 代表氢原子、烷基、环烷基、芳基、芳烷基或酰基，或共同 代表一个原子团，该原子团形成一个含有氮原子的 5 或 6 嵌合环，R1 和 R2 与该环键合；R3 代表氢原子、烷基、环烷基、芳基或芳基烷基团；以及 R4 代表烷基、环烷基、芳基或芳基烷基团。
• LIQUID PROPELLANT
  申请人：Carlit Holdings Co. Ltd.

  公开号：EP2927204A1

  公开（公告）日：2015-10-07

  The present invention addresses the problem of providing a liquid propellant which has low toxicity, is easy to handle, and has excellent specific impulse. The present invention provides a liquid propellant characterized by comprising at least a dinitramide derivative represented by general formula (1) and an amine nitrate represented by general formula (2).

  本发明要解决的问题是提供一种毒性低、易于处理、比冲力大的液体推进剂。本发明提供了一种液体推进剂，其特征在于至少包含通式（1）代表的二硝胺衍生物和通式（2）代表的硝酸胺。