2-amino-4-(4,9,13-triazatridecyl)amino-6,7-dimethylpteridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 2-amino-4-(4,9,13-triazatridecyl)amino-6,7-dimethylpteridine
• 英文别名: 4-N-[3-[4-(3-aminopropylamino)butylamino]propyl]-6,7-dimethylpteridine-2,4-diamine
• 化学式: C₁₈H₃₃N₉
• 分子量: 375.52
• InChiKey: GFPPNCZXSZVVKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  27
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  140
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  4-pentyloxy-6,7-dimethylpterin 、 精胺 反应 48.0h， 以50%的产率得到2-amino-4-(4,9,13-triazatridecyl)amino-6,7-dimethylpteridine
  参考文献：
  名称：

  Specific Formation of Beads-on-a-Chain Structures on Giant DNA Using a Designed Polyamine Derivative

  摘要：

  Fluorescence microscopy was used to study the folding transition of giant DNAs, T4 DNA (ca. 166 kbp), and lambda DNA (ca. 48 kbp), which proceeds through intermediates with intramolecular segregation induced by pteridine-polyamine conjugates, i.e., 2-amino-6,7-dimethyl-4-(4,9,13-triazatridecylamino) pteridine and -4-(3-(aminopropyl)amino)pteridine. According to the results of DNA denaturation, UV and fluorescent spectroscopy, and transmission electron microscopic observations, it became clear that DNA folding induced by the polyamine derivative is not a continuous shrinking process but a combination of discontinuous processes.

  DOI：

  10.1021/ja042509q

文献信息

• Specific Formation of Beads-on-a-Chain Structures on Giant DNA Using a Designed Polyamine Derivative
  作者：Ning Chen、Anatoly A. Zinchenko、Shizuaki Murata、Kenichi Yoshikawa

  DOI：10.1021/ja042509q

  日期：2005.8.1

  Fluorescence microscopy was used to study the folding transition of giant DNAs, T4 DNA (ca. 166 kbp), and lambda DNA (ca. 48 kbp), which proceeds through intermediates with intramolecular segregation induced by pteridine-polyamine conjugates, i.e., 2-amino-6,7-dimethyl-4-(4,9,13-triazatridecylamino) pteridine and -4-(3-(aminopropyl)amino)pteridine. According to the results of DNA denaturation, UV and fluorescent spectroscopy, and transmission electron microscopic observations, it became clear that DNA folding induced by the polyamine derivative is not a continuous shrinking process but a combination of discontinuous processes.