MRS 2798 | 102783-72-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: MRS 2798
• 英文别名: 2'-deoxyguanosine-5'-tetraphosphate；dG4P；P-P-P-P-dGuo；[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate
• CAS: 102783-72-2
• 化学式: C₁₀H₁₇N₅O₁₆P₄
• 分子量: 587.164
• InChiKey: UOUJZUPPXXZTSU-KVQBGUIXSA-N

物化性质

• 密度：
  2.74±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -6.7
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  321
• 氢给体数：
  8
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  2'-脱氧鸟苷 在 磷酸三甲酯 、 三正丁胺 、 tris[tributylammonium] triphosphate 、 三氯氧磷 作用下， 以 乙腈 为溶剂， 反应 0.6h， 生成 MRS 2798
  参考文献：
  名称：

  A new, facile, and protection-free one-pot chemical synthesis of 2′-deoxynucleoside-5′-tetraphosphates

  摘要：

  A new straight forward, reliable, and an efficient method for the chemical synthesis of 2'-deoxynucleoside-5'-tetraphosphate is reported. The present 'one-pot, three step' synthetic strategy involves the monophosphorylation of nucleoside followed by reaction with tris-(tri-n-butylammonium) triphosphate and hydrolysis of the putative cyclic tetrametaphosphate intermediate to provide the corresponding 2'-deoxynucleoside-5'-tetraphosphate in moderate yield with high purity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.08.071

文献信息

• [EN] CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES<br/>[FR] PROCÉDÉS CHIMIQUES POUR PRODUIRE DES NUCLÉOTIDES ÉTIQUETÉS
  申请人：TRUSTEES OF COLUMBIA UNIVERISTY IN THE CITY OF NEW YORK

  公开号：WO2015148402A1

  公开（公告）日：2015-10-01

  This disclosure provides systems and methods for attaching nano pore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disdosed tagged nudeotides. Provided herein are nudeotides with attached tags and methods for attaching tags to nudeotides. The tags can be attached by chemical reactions, such as "dick chemistry". In an aspect, the present disdosure provides a tagged nudeotide, comprising: (a) a poly-phosphate moiety having a terminal phosphate; and (b) a tag covalently coupled to the terminal phosphate of the nudeotide by a triazole, a 1,2-diazine, a disulfide, a secondary amine, a hydrazone, a thio-acetamide, or a maleimide-thioadduct.

  本公开提供了一种将纳米孔可检测标签附着到核苷酸上的系统和方法。该公开还提供了使用所述标记的核苷酸进行核酸测序的方法。本文提供了附有标签的核苷酸及将标签附着到核苷酸上的方法。这些标签可以通过化学反应，如“迪克化学”来附着。在一个方面，本公开提供了一种带有标签的核苷酸，包括：(a) 具有末端磷酸的多磷酸基团；和 (b) 通过三唑、1,2-二氮杂环、二硫化物、次级胺、醛缩酸酰肼、硫代乙酰胺或马来酰亚胺硫加合物与核苷酸的末端磷酸共价偶联的标签。
• Chemical methods for producing tagged nucleotides
  申请人：Fuller Carl W.

  公开号：US10240195B2

  公开（公告）日：2019-03-26

  This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.

  本公开提供了在核苷酸上附加纳米孔可检测标签的系统和方法。本公开还提供了使用所公开的标记核苷酸对核酸进行测序的方法。
• Method of preparation of nanopore and uses thereof
  申请人：Ju Jingyue

  公开号：US10246479B2

  公开（公告）日：2019-04-02

  This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.

  本公开提供了使用核苷酸类似物对核酸进行测序的系统和方法，以及通过纳米孔检测掺入核苷酸类似物的标记的易位情况。在某些方面，本公开涉及使用标记分子对核酸进行测序的组合物、方法和系统，以及通过纳米孔检测掺入分子释放的标记的易位。
• LARGE STOKES SHIFT DYES
  申请人：Life Technologies Corporation

  公开号：EP2396318A2

  公开（公告）日：2011-12-21
• METHOD OF PREPARATION OF NANOPORE AND USES THEREOF
  申请人：The Trustees of Columbia University in the City of New York

  公开号：EP2836604A2

  公开（公告）日：2015-02-18