9-chloro-9-anisylxanthen | 95985-09-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 9-chloro-9-anisylxanthen
• 英文别名: 9-chloro-9-(p-anisoyl)xanthane；9-p-Anisyl-9-chlorxanthen；9-chloro-9-(4-methoxy-phenyl)-xanthene；9-Chlor-9-(4-methoxy-phenyl)-xanthen；9-Chloro-9-(4-methoxyphenyl)xanthene
• CAS: 95985-09-4
• 化学式: C₂₀H₁₅ClO₂
• 分子量: 322.791
• InChiKey: WGYVLGIVUOERDU-UHFFFAOYSA-N

物化性质

• 沸点：
  420.1±45.0 °C(Predicted)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9-chloro-9-anisylxanthen 在 air 、 银 、 苯 作用下， 生成 bis-[9-(4-methoxy-phenyl)-xanthen-9-yl]-peroxide
  参考文献：
  名称：

  Gomberg; West, Journal of the American Chemical Society, 1912, vol. 34, p. 1556

  摘要：

  DOI：
• 作为产物：
  描述：

  9-对甲氧苯基占顿-9-醇 在 乙酰氯 作用下， 以 苯 为溶剂， 以9.15 g的产率得到9-chloro-9-anisylxanthen
  参考文献：
  名称：

  Gaffney, Piers R. J.; Changsheng, Liu; Rao, M. Vaman, Journal of the Chemical Society. Perkin transactions I, 1991, # 6, p. 1355 - 1360

  摘要：

  DOI：

文献信息

• New regiospecific synthesis of the “branched” tri-, penta- & hepta-ribonucleic acids which are formed as the “lariat” in the pre-mRNA processing reactions[Splicing]
  作者：X-. Zhou、G. Remaud、J. Chattopadhyaya

  DOI：10.1016/s0040-4020(01)89837-9

  日期：——

  Synthesis of branched triribonucleotides 14 & 19, branched pentaribonucleotides 37 & 38 and branched heptaribonucleotide 41 are reported using the key intermediate 7 or 9. The advantage of using 7 or 9 is that they circumvent the need for complementary protecting groups for the 2'-hydroxyl functions and for the internucleotidyl phosphodiesters in order to introduce the second phosphodiester bond specifically

  使用关键中间体7或9报告了支链三核糖核苷酸14和19，支链五核糖核苷酸37和38和支链七核糖核苷酸41的合成。使用7或9的优点是它们避免了对于2'-羟基官能团和核苷酸间磷酸二酯的互补保护基的需要，以便特别地在分支点引入第二磷酸二酯键。所有支化的核糖核苷酸14，19，37，38和411 H-和31 P-NMR光谱已明确表征。
• Nucleoside derivatives and antiherpes composition
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：EP0617046A1

  公开（公告）日：1994-09-28

  Disclosed is a novel nucleoside derivative showing anti-virus activities such as an anti-herpes activity and an anti-HIV activity. The nucleoside derivative has the formula (1-1) or (1-2): wherein A is a nitrogen atom-containing heterocyclic ring which is linked through nitrogen atom thereof; B is a hydrogen atom, a halogen atom, an azido group, an alkyl group, etc.

  公开了一种新型核苷衍生物，具有抗病毒活性，例如抗疱疹活性和抗HIV活性。该核苷衍生物的化学式为(1-1)或(1-2)：其中，A是一种含氮杂环环，通过其中的氮原子连接；B是氢原子、卤素原子、叠氮基团、烷基等。
• Medicament for treating human immunodeficiency virus
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：EP0624372A2

  公开（公告）日：1994-11-17

  Disclosed is a medicament for treating human immunodeficiency virus containing a novel nucleoside derivative. The nucleoside derivative has the formula (1-1) or (1-2): wherein A is a nitrogen atom-containing heterocyclic ring which is linked through nitrogen atom thereof; B is a hydrogen atom, a halogen atom, an azido group, an alkyl group, etc.

  公开了一种治疗人类免疫缺陷病毒的药物，其中含有一种新型核苷衍生物。该核苷衍生物具有式（1-1）或（1-2）： 其中 A 是通过氮原子连接的含氮杂环；B 是氢原子、卤素原子、叠氮基团、烷基等。
• A New Method for Removal of Modified Trityl and Pixyl Groups by Use of an Acid Species Generated by Reaction of Diethyl Oxomalonate with Methanol
  作者：Mitsuo Sekine

  DOI：10.1080/15257779408012160

  日期：1994.7

  Diethyl oxomalonate (DEOM) was found to exhibit unique properties as a new type of detritylating reagent in the presence of methanol. A variety of deoxyribonucleoside derivatives protected with modified trityl groups were allowed to react with DEOM. The ease of detritylation highly depended on the basicity of protected bases of adenine, guanine and cytosine. Inhibitory effects of various amines possessing the pKa values between 0.79-10.87 on the present detritylation were studied. Several mechanistic considerations were alsb discussed on the basis of H-1 and C-13 NMR studies of the DEOM-Methanol adduct.
• Kwiatkowski, M.; Chattopadhyaya, J., Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1984, vol. 38, # 8, p. 657 - 672
  作者：Kwiatkowski, M.、Chattopadhyaya, J.

  DOI：——

  日期：——