bis-(2-chloro-ethoxycarbonyl)-peroxide | 34037-78-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: bis-(2-chloro-ethoxycarbonyl)-peroxide
• 英文别名: μ-Peroxo-dikohlensaeure-bis-(2-chlor-aethylester)；Bis-(2-chlor-aethoxycarbonyl)-peroxid；1,1'-[Peroxybis(carbonyloxy)]bis(chloroethane)；2-chloroethoxycarbonyloxy 2-chloroethyl carbonate
• CAS: 34037-78-0
• 化学式: C₆H₈Cl₂O₆
• 分子量: 247.032
• InChiKey: LENMFXPGQLGNOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 危险等级：
  5.2
• 危险品运输编号：
  UN 3103
• 海关编码：
  2909600000
• 包装等级：
  II
• 危险类别：
  5.2

反应信息

• 作为反应物：
  描述：

  bis-(2-chloro-ethoxycarbonyl)-peroxide 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Effects of oral and transdermal 17β-estradiol with cyclical oral norethindrone acetate on insulin sensitivity, secretion, and elimination in postmenopausal women

  摘要：

  Few studies have examined the effects of 17 beta-estradiol on parameters of insulin and glucose metabolism. We studied 42 healthy, untreated postmenopausal women seeking relief from menopausal symptoms. They were randomized to receive either oral 17 beta-estradiol 2 mg daily combined with sequential oral norethindrone acetate (NETA) 1 mg daily from days 12 to 22, or transdermal 17 beta-estradiol 0.05 mg daily combined with sequential oral NETA 1 mg daily from days 17 to 28. Intravenous glucose tolerance tests (IVGTTs) were performed at baseline and after 48 weeks (estrogen-alone phase) and 48 weeks (combined phase) of completed therapy. Mathematical modeling analysis of plasma glucose, insulin, and C-peptide concentration profiles provided measures of insulin resistance, secretion, and elimination. Both types of therapy were associated with a decrease in fasting insulin and glucose levels. Insulin sensitivity was increased by oral estradiol during the estrogen-alone phase but was reversed by the addition of NETA. Transdermal estradiol did not affect insulin sensitivity. Hepatic insulin uptake and insulin secretion were increased with both types of treatment. The oral regimen of estradiol therapy was favorable to both insulin elimination and sensitivity. Transdermal estradiol therapy had relatively few effects on insulin metabolism. Copyright (C) 2000 by W.B. Saunders Company.

  DOI：

  10.1053/meta.2000.6238
• 作为产物：
  描述：

  氯甲酸氯乙酯 在 sodium peroxide 、 乙醚 作用下， 生成 bis-(2-chloro-ethoxycarbonyl)-peroxide
  参考文献：
  名称：

  Sortieren von Kunststoffen durch thermisch beeinflusste Hafteigenschaften

  摘要：

  DOI：

  10.1002/1522-2640(200011)72:11<1382::aid-cite1382>3.0.co;2-y

文献信息

• US4143011A
  申请人：——

  公开号：US4143011A

  公开（公告）日：1979-03-06
• Effects of oral and transdermal 17β-estradiol with cyclical oral norethindrone acetate on insulin sensitivity, secretion, and elimination in postmenopausal women
  作者：Christopher P. Spencer、Ian F. Godsland、Alison J. Cooper、David Ross、Malcolm I. Whitehead、John C. Stevenson

  DOI：10.1053/meta.2000.6238

  日期：2000.6

  Few studies have examined the effects of 17 beta-estradiol on parameters of insulin and glucose metabolism. We studied 42 healthy, untreated postmenopausal women seeking relief from menopausal symptoms. They were randomized to receive either oral 17 beta-estradiol 2 mg daily combined with sequential oral norethindrone acetate (NETA) 1 mg daily from days 12 to 22, or transdermal 17 beta-estradiol 0.05 mg daily combined with sequential oral NETA 1 mg daily from days 17 to 28. Intravenous glucose tolerance tests (IVGTTs) were performed at baseline and after 48 weeks (estrogen-alone phase) and 48 weeks (combined phase) of completed therapy. Mathematical modeling analysis of plasma glucose, insulin, and C-peptide concentration profiles provided measures of insulin resistance, secretion, and elimination. Both types of therapy were associated with a decrease in fasting insulin and glucose levels. Insulin sensitivity was increased by oral estradiol during the estrogen-alone phase but was reversed by the addition of NETA. Transdermal estradiol did not affect insulin sensitivity. Hepatic insulin uptake and insulin secretion were increased with both types of treatment. The oral regimen of estradiol therapy was favorable to both insulin elimination and sensitivity. Transdermal estradiol therapy had relatively few effects on insulin metabolism. Copyright (C) 2000 by W.B. Saunders Company.
• Sortieren von Kunststoffen durch thermisch beeinflusste Hafteigenschaften
  作者：Sergej Aman、Jürgen Tomas

  DOI：10.1002/1522-2640(200011)72:11<1382::aid-cite1382>3.0.co;2-y

  日期：2000.11