zinc;oxoarsinite | 10326-24-6

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 类金属有机物
• 英文名称: zinc;oxoarsinite
• 英文别名: Zinc metaarsenite
• CAS: 10326-24-6
• 化学式: As₂O₄Zn
• 分子量: 279.2
• InChiKey: USWSXCHQCPHCDI-UHFFFAOYSA-L

物化性质

• 溶解度：
  不溶于水；溶于酸溶液

计算性质

• 辛醇/水分配系数(LogP)：
  -3.38
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

代谢

锌可以通过肺部、皮肤和胃肠系统进入人体。肠道对锌的吸收是由锌载体蛋白CRIP控制的。锌还与金属硫蛋白结合，帮助防止过量锌的吸收。锌在体内广泛分布，存在于所有组织和组织液中，尤其在肝脏、胃肠道、肾脏、皮肤、肺、大脑、心脏和胰腺中含量较高。在血液中，锌与红细胞中的碳酸酐酶结合，也与血浆中的白蛋白、α2-巨球蛋白和氨基酸结合。白蛋白和氨基酸结合的锌可以通过组织膜扩散。锌通过尿液和粪便排出体外。砷主要通过吸入或摄入吸收，其次是通过皮肤接触。之后，砷会分布到全身，如果有必要，会被还原成亚砷酸盐，然后通过亚砷酸盐甲基转移酶甲基化成单甲基砷（MMA）和二甲砷酸（DMA）。砷及其代谢物主要通过尿液排出体外。已知砷能诱导金属结合蛋白金属硫蛋白，通过结合砷和其他金属使它们生物活性失效，并作为抗氧化剂，从而减少砷和其他金属的有毒效果。

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20, L49)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

缺铁性贫血是由于锌的过量吸收抑制了铜和铁的吸收，这很可能是通过肠道粘膜细胞的竞争性结合实现的。铜和锌与铜锌超氧化物歧化酶结合的不平衡水平与肌萎缩侧索硬化症（ALS）有关。胃酸能溶解金属锌，生成腐蚀性的氯化锌，这可能会对胃壁造成损害。金属烟雾热被认为是对吸入锌的免疫反应。砷及其代谢物通过多种机制干扰ATP的产生。在柠檬酸循环层面，砷抑制了丙酮酸脱氢酶，并通过与磷酸盐竞争，解耦了氧化磷酸化，从而抑制了与能量相关的NAD+的还原、线粒体呼吸和ATP合成。过氧化氢的产生也增加了，这可能会形成活性氧种和氧化应激。砷的致癌性受到砷与微管蛋白结合的影响，这会导致非整倍体、多倍体和有丝分裂停止。其他砷蛋白靶点的结合也可能导致DNA修复酶活性改变、DNA甲基化模式改变和细胞增殖增加。(T1, A17, L48, L49, A49)

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17, L48, L49, A49)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

1, 对人类致癌。

1, carcinogenic to humans. (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

慢性接触锌会导致贫血、运动失调、乏力，并降低体内良好胆固醇的水平。还认为它会导致胰腺和生殖损害。砷中毒可能导致多系统器官衰竭死亡，可能是由于坏死的细胞死亡，而非凋亡。砷也是一种已知的致癌物，尤其是在皮肤、肝脏、膀胱和肺癌中。

Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20, L49)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L2）；吸入（L2）；皮肤（L2）

Oral (L2) ; inhalation (L2) ; dermal (L2)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

摄入大剂量的锌会导致胃痉挛、恶心和呕吐。急性吸入大量锌会导致金属烟雾热，其特征是寒战、发热、头痛、乏力、鼻和喉咙干燥、胸痛和咳嗽。皮肤接触锌会导致皮肤刺激。暴露于较低水平的砷会导致恶心和呕吐、红细胞和白细胞的生成减少、心律异常、血管损伤和

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of

来源:Toxin and Toxin Target Database (T3DB)

安全信息

• 危险等级：
  6.1(a)
• 危险品运输编号：
  UN 1712
• 海关编码：
  28429090
• 包装等级：
  II
• 危险类别：
  6.1(a)

SDS

第一部分：化学品名称

反应信息

• 作为产物：
  描述：

  苯丙醛 、 三羟甲基硝基甲烷 在 硫酸 作用下， 生成 zinc;oxoarsinite
  参考文献：
  名称：

  Malinowski; Urbanski, Roczniki Chemii, 1951, vol. 25, p. 183,196

  摘要：

  DOI：

文献信息

• Malinowski; Urbanski, Roczniki Chemii, 1951, vol. 25, p. 183,196
  作者：Malinowski、Urbanski

  DOI：——

  日期：——