N,O-Bis(trimethylsilyl)acetaimidat | 203784-65-0

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: N,O-Bis(trimethylsilyl)acetaimidat
• 英文别名: [²H₁₈]-BSA；N,O-Bis(trimethyl-d9-silyl)acetamide >90%；tris(trideuteriomethyl)silyl N-[tris(trideuteriomethyl)silyl]ethanimidate
• CAS: 203784-65-0
• 化学式: C₈H₂₁NOSi₂
• 分子量: 221.289
• InChiKey: SIOVKLKJSOKLIF-WNBQGSQPSA-N

物化性质

• 熔点：
  24 °C
• 沸点：
  71-73 °C35 mm Hg(lit.)
• 密度：
  0.869 g/mL at 25 °C
• 闪点：
  44 °C
• 溶解度：
  溶于氯仿

计算性质

• 辛醇/水分配系数(LogP)：
  3.09
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品运输编号：
  UN 2920 8/PG 2

制备方法与用途

三甲基甲硅烷基N-(三甲基甲硅烷基)乙酰化物-d18是一种含有氘标记的三甲基甲硅烷基N-(三甲基甲硅烷基)乙酰化物，常用于同位素研究[1]。

反应信息

• 作为反应物：
  描述：

  4-羟基-睾酮 、 N,O-Bis(trimethylsilyl)acetaimidat 在 碘化铵 、 2-巯基乙醇 作用下， 反应 0.5h， 生成
  参考文献：
  名称：

  甲酸甲酯的深入GC-MS / MS碎片分析和异美3-酮4-烯羟基类固醇的质谱鉴别评估。

  摘要：

  芳香酶抑制剂福尔马坦（4-羟基雄烷-4-烯-3,17-二酮）被列入世界反兴奋剂机构的《运动中禁用物质清单》。但是，它也像2-，6-和11-羟基异构体一样内源性地发生。这项研究的目的是使用GC / EI-MS区分不同的异构体，以增强检测的信心和测定的选择性。

  DOI：

  10.1002/rcm.8937

文献信息

• Identification and Stereochemical Characterization of Lignans in Flaxseed and Pumpkin Seeds
  作者：Tina Sicilia、Heike B. Niemeyer、Doris M. Honig、Manfred Metzler

  DOI：10.1021/jf0207979

  日期：2003.2.1

  Phytoestrogens of the lignan type are widely distributed in plant-derived food items and are believed to protect against hormone-dependent cancer. The richest known dietary source of lignans is flaxseed. Flaxseed has been reported to contain glycosides of secoisolariciresinol as the major lignan, together with small amounts of matairesinol, isolariciresinol, and pinoresinol. Secoisolariciresinol, but none of the other lignans, has so far been identified in pumpkin seeds. In the present study, two different methods for the hydrolysis of lignan glycosides are compared. Artifact formation and loss of lignans under acidic conditions were observed. Lariciresinol was identified by GC-MS analysis in two different types of flaxseed (Linum usitatissimum L. and Linum flavum L.) and in pumpkin seeds (Cucurbita pepo L.) for the first time. Likewise, the novel lignan demethoxy-secoisolariciresinol was tentatively identified in the flaxseed samples. Stereochemical analysis by chiral HPLC of several lignans isolated from flaxseed showed that secoisolariciresinol, matairesinol, and lariciresinol consisted predominantly of one enantiomer.
• Koenig, Wilfried A.; Drautz, Hannelore; Zaehner, Hans, Liebigs Annalen der Chemie, 1980, # 9, p. 1384 - 1391
  作者：Koenig, Wilfried A.、Drautz, Hannelore、Zaehner, Hans

  DOI：——

  日期：——
• In‐depth gas chromatography/tandem mass spectrometry fragmentation analysis of formestane and evaluation of mass spectral discrimination of isomeric 3‐keto‐4‐ene hydroxy steroids
  作者：Annette Sophie Kollmeier、Xavier Torre、Christian Müller、Francesco Botrè、Maria Kristina Parr

  DOI：10.1002/rcm.8937

  日期：2020.12.30

  The aromatase inhibitor formestane (4‐hydroxyandrost‐4‐ene‐3,17‐dione) is included in the World Anti‐Doping Agency’s List of Prohibited Substances in Sport. However, it also occurs endogenously as do its 2‐, 6‐ and 11‐hydroxy isomers. The aim of this study is to distinguish the different isomers using GC/EI‐MS for enhanced confidence in detection and selectivity for determination.

  芳香酶抑制剂福尔马坦（4-羟基雄烷-4-烯-3,17-二酮）被列入世界反兴奋剂机构的《运动中禁用物质清单》。但是，它也像2-，6-和11-羟基异构体一样内源性地发生。这项研究的目的是使用GC / EI-MS区分不同的异构体，以增强检测的信心和测定的选择性。