1-(Dichloro-methyl-silanyl)-3-{tris-[3-(dichloro-methyl-silanyl)-propyl]-silanyl}-propane | 175167-99-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1-(Dichloro-methyl-silanyl)-3-{tris-[3-(dichloro-methyl-silanyl)-propyl]-silanyl}-propane
• 英文别名: Tetrakis[3-[dichloro(methyl)silyl]propyl]silane
• CAS: 175167-99-4
• 化学式: C₁₆H₃₆Cl₈Si₅
• 分子量: 652.513
• InChiKey: UITMQQVOCVRLLI-UHFFFAOYSA-N

物化性质

• 沸点：
  460.8±30.0 °C(Predicted)
• 密度：
  1.160±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  11.19
• 重原子数：
  29
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  三甘醇单甲醚 、 1-(Dichloro-methyl-silanyl)-3-{tris-[3-(dichloro-methyl-silanyl)-propyl]-silanyl}-propane 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 15.0h， 以74%的产率得到Tetrakis[3-[bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-methylsilyl]propyl]silane
  参考文献：
  名称：

  三（乙二醇）和聚（乙二醇）醚末端接枝的碳硅氧烷和碳硅烷树枝状大分子：合成和反应行为

  摘要：

  讨论了TEG-[三(乙二醇)单甲醚]和PEG-[聚(乙二醇)单甲醚]封端的第1-3代碳硅氧烷和碳硅烷树枝状大分子的制备。Si(OCH 2 CH 2 CH 2 SiMe-XCl) 4 (la, X = Me; 1b, X = Cl) 与 HO(CH 2 CH 2 O) n Me (2a, n = 3, TEG; 2b, n = 7.3, PEG) 得到合适的树枝状大分子 Si[OCH 2 CH 2 CH 2 SiMe 2 O(CH 2 CH 2 O) n Me] 4 (3a, n = 3; 3b, n = 7.3) 和 Si{OCH 2 CH 2 CH 2 SiMe[O(CH 2 CH 2 O) n Me] 2 } 4 (4a. n=3; 4b, n = 7.3)。以类似的方式，第 2 代和第 3 代碳硅氧烷树枝状大分子 Si(OCH 2 CH 2 CH 2 SiMe({OCH 2 CH 2

  DOI：

  10.1055/s-2004-831246
• 作为产物：
  描述：

  甲基二氯硅烷 、 四烯丙基硅烷 在 bis(divinyltetramethyldisiloxane)platinum⁽⁰⁾ 作用下， 以 xylene 为溶剂， 生成 1-(Dichloro-methyl-silanyl)-3-{tris-[3-(dichloro-methyl-silanyl)-propyl]-silanyl}-propane
  参考文献：
  名称：

  Organometallic silicon dendrimers

  摘要：

  合成并鉴定了第一批有机金属硅树枝状大分子，其中含有数量可控的氧化还原活性中心。

  DOI：

  10.1039/c39940002575

文献信息

• Novel Water‐Soluble Carbosilane Dendrimers: Synthesis and Biocompatibility
  作者：Paula Ortega、Jesus F. Bermejo、Louis Chonco、Ernesto de Jesus、F. Javier de la Mata、Gerónimo Fernández、Juan Carlos Flores、Rafael Gómez、M. Jesús Serramía、M. Angeles Muñoz‐Fernandez

  DOI：10.1002/ejic.200500782

  日期：2006.4

  ammonium-terminated carbosilane dendrimers of type nG-[Si(OCH2CH2NMe2)y]x or nG-[Si(OCH2CH2NMe3+I–)y]x, respectively. It consists of the alcoholysis of well-known chlorosilane-terminated dendrimers with N,N-dimethylethanolamine and the subsequent quaternization with MeI. All these systems are susceptible to hydrolysis, although the decomposition depends on concentration and dendrimer generation. Evaluation

  已经开发了一种合成策略，用于制备分别为 nG-[Si(OCH2CH2NMe2)y]x 或 nG-[Si(OCH2CH2NMe3+I-)y]x 型的新型外围胺或铵封端碳硅烷树枝状聚合物。它由众所周知的氯硅烷封端的树枝状聚合物与 N,N-二甲基乙醇胺的醇解和随后与 MeI 的季铵化组成。尽管分解取决于浓度和树枝状聚合物的生成，但所有这些系统都易于水解。通过相差光学显微镜和 MTT 测定评估树枝状聚合物的毒性，并通过凝胶电泳进行树枝状聚合物/寡核苷酸复合物形成的证据。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
• Structural Defects in Polyallylcarbosilane Dendrimers and Their Polyol Derivatives Characterized by NMR and MALDI-TOF Mass Spectrometry
  作者：Alena Krupková、Jan Čermák、Zuzana Walterová、Jiří Horský

  DOI：10.1021/ma100315w

  日期：2010.5.25

  A series of polyallylcarbosilane dendrimers and carbosilane-based dendritic polyols up to third generation was analyzed by means of matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry and multinuclear NMR spectroscopy to determine the character, origin, and number of structural defects. Besides occasionally reported alpha-hydrosilylation, several side reactions accompanying hydrosilylation, such as isomerization of terminal double bonds, were detected during the synthesis of carbosilane skeleton. Despite increased steric hindrance, internal double bonds react in subsequent addition reactions. Depending on the synthetic sequence applied, the retained reactivity of the internal double bonds can lead either to suppression of the defect in the next generation or to creation of more significant defects such as dendrimer dimers. Hydroboration of allyl groups using dicyclohexylborane proceeded with near quantitative conversion: a small amount of hydrolysis accompanying the following oxidation step producing nonreactive alkyl groups at the periphery was detected.
• Synthesis of Carbosilane Dendrimers with Variable Distance between Branching Nodes
  作者：E. A. Rebrov、I. D. Leshchiner、A. M. Muzafarov

  DOI：10.1021/ma300957d

  日期：2012.11.13

  A principal possibility to synthetically control the distance between the branching nodes of poly(propenylsilane) dendrimer molecules has been shown This was achieved by performing a relatively simple procedure-adding to the classic dendrimer building process a stage involving a bifunctional reagent: dimethylchlorosilane. As a result two series of carbosilane dendrimers with doubled node-to-node distance, from previously achieved, were synthesized which. differed by the distribution pattern of terminal allyl groups. A sixth generation dendrimer with varied node-to-node distance in the core and periphery had been synthesized. These compounds were isolated by preparative LC and were characterized by H-1, C-13, and Si-29 NMR, Mass Spectroscopy, and GPC. Their characteristic viscosities and hydrodynamic diameters were identified. A comparative analysis of properties of synthesized dendrimers and their counterparts from half the distance between the branch nodes had been performed.
• Carbosilane Metallodendrimers with Titanocene Dichloride End Groups
  作者：Tomáš Strašák、Jan Čermák、Jan Sýkora、Jiří Horský、Zuzana Walterová、Florian Jaroschik、Dominique Harakat

  DOI：10.1021/om300559y

  日期：2012.10.8

  Carbosilane metallodendrimers containing substituted titanocene dichloride end groups were prepared using hydrosilylation as the capping reaction. Two complementary pathways were followed: hydrosilylation of omega-alkenyl-substituted titanocene dichloride complexes with Si H bond terminated dendrimers and hydrosilylation of vinyl terminated dendritic materials with 3-(dimethylsilyl)propyl-substituted titanocene dichloride. The former procedure provided dendrimers of the first generation with four end units and of the second generation with eight end units. The latter method gave dendrititic wedges and dendrimers up to the second generation with 16 peripheral titanocene dichloride units and molecular weight 7070 Da. Dendritic materials were purified by GPC and characterized by MALDI-TOF mass spectrometry and ESI-TOF mass spectrometry (metallodendrimers) and also by multinuclear NMR.