21-Fluoro-17-alpha-hydroxy-6-alpha-methylpregn-4-ene-3,20-dione acetate (ester) | 3185-11-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 21-Fluoro-17-alpha-hydroxy-6-alpha-methylpregn-4-ene-3,20-dione acetate (ester)
• 英文别名: [(6S,8R,9S,10R,13S,14S,17R)-17-(2-fluoroacetyl)-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
• CAS: 3185-11-3
• 化学式: C₂₄H₃₃FO₄
• 分子量: 404.5
• InChiKey: XEQJIVJGTBOOER-USTFCYDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Compositions comprising encapsulated particles
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0076158A2

  公开（公告）日：1983-04-06

  A composition which comprises at least one solid or liquid particle comprising at least one active substance, the or a plurality of such particles being encapsulated by the in situ cationic (co)polymerisation thereon of at least one cationically polymerisable monomer or prepolymer.

  一种组合物，它包括至少一种含有至少一种活性物质的固体或液体微粒，这些微粒或多个微粒被至少一种可阳离子聚合的单体或预聚合体原位阳离子（共）聚合包裹。
• Sustained release compositions
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0076636A1

  公开（公告）日：1983-04-13

  A non-crosslinked derivative formable by reacting at least one substituted or unsubstituted, saturated or unsaturated, mono-, di- or poly-carboxy, hydroxy or mercapto hydrocarbon with at least one cyclic unsaturated (thio)ether.

  至少一种取代或未取代、饱和或不饱和、单羧基、二羧基或多羧基、羟基或巯基碳氢化合物与 至少一种环状不饱和（硫）醚反应而形成的非交联衍生物。
• Controlled release device
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0132384A2

  公开（公告）日：1985-01-30

  A controlled release device which comprises: (i) a hydrogel; and incorporated therewith (ii) an active substance, at least part of at least one surface of the device comprising (iii) a layer which is impermeable to aqueous media.

  一种控释装置，包括 (i) 水凝胶；并与之结合 (ii) 一种活性物质、 (iii) 不透水介质层。
• NOVEL PROGESTERONE COMPOUND AND USE THEREOF
  申请人：MEIJI MILK PRODUCTS COMPANY LIMITED

  公开号：EP0754701A1

  公开（公告）日：1997-01-22

  A progesterone compound represented by the following formula (1): [wherein R1 represents a C1-C23 hydrocarbon group], and a neovascularization inhibitor containing the same as the active ingredient. The compound (1) has a potent neovascularization inhibitory effect and is hence useful as a remedy for malignant tumors, diabetic retinitis, rheumatism, etc.

  由下式(1)代表的孕酮化合物： [其中 R1 代表 C1-C23 烃基]，以及一种含有相同活性成分的新生血管抑制剂。 化合物（1）具有强效的血管新生抑制作用，因此可用于治疗恶性肿瘤、糖尿病视网膜炎、风湿病等。
• IMMUNOGENIC COMPOSITIONS
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0168401A1

  公开（公告）日：1986-01-22