荧光素 单-4-胍基苯甲酸酯盐酸盐 | 83616-10-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 荧光素 单-4-胍基苯甲酸酯盐酸盐
• 中文别名: 乙酰腈,2-(3-氨基-4-甲基苯氧基)-；荧光素单-4-胍基苯甲酸酯盐酸盐
• 英文名称: fluorescein mono-p-guanidinobenzoate hydrochloride
• 英文别名: hydron;(6'-hydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) 4-(diaminomethylideneamino)benzoate;chloride
• CAS: 83616-10-8
• 化学式: C₂₈H₁₉N₃O₆*ClH
• 分子量: 529.936
• InChiKey: TZOYWBUCJYLOLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.51
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  147
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  荧光素 单-4-胍基苯甲酸酯盐酸盐 在 碳酸氢钠 作用下， 以 various solvent(s) 为溶剂， 生成 荧光素
  参考文献：
  名称：

  p-Guanidinobenzoic acid esters of fluorescein as active-site titrants of serine proteases

  摘要：

  DOI：

  10.1021/ja00389a065
• 作为产物：
  描述：

  fluorescein di-p-guanidinobenzoate dihydrochloride 在 碳酸氢钠 作用下， 以 various solvent(s) 为溶剂， 生成 荧光素 单-4-胍基苯甲酸酯盐酸盐
  参考文献：
  名称：

  p-Guanidinobenzoic acid esters of fluorescein as active-site titrants of serine proteases

  摘要：

  DOI：

  10.1021/ja00389a065

文献信息

• Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 1 (DPP1)
  申请人：Bayer HealthCare AG

  公开号：EP2017620A2

  公开（公告）日：2009-01-21

  The invention provides a human DPP1 which is associated with the infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastro-enterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastro-enterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP1 as well as pharmaceutical compositions comprising such compounds.

  本发明提供了一种与感染、心血管疾病、呼吸系统疾病、癌症、内分泌疾病、代谢疾病、胃肠病、炎症、血液病、肌肉骨骼疾病、神经系统疾病和泌尿系统疾病有关的人DPP1。本发明还提供了用于鉴定治疗或预防感染、心血管疾病、呼吸系统疾病、癌症、内分泌疾病、代谢疾病、胃肠病、炎症、血液病、肌肉骨骼疾病、神经系统疾病和泌尿系统疾病的化合物的检测方法。本发明还包括与 DPP1 结合和/或激活或抑制 DPP1 活性的化合物以及包含此类化合物的药物组合物。
• HUMAN SERINE PROTEASE
  申请人：——

  公开号：US20020164324A1

  公开（公告）日：2002-11-07

  Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic, and industrial contexts. Ztryp3 is a new member of the serine protease family.

  丝氨酸蛋白酶家族的成员在血液凝固、纤维蛋白溶解、补体激活、受精和激素分泌等严格控制的过程中发挥作用。这些酶还被用于各种诊断、治疗和工业领域。Ztryp3 是丝氨酸蛋白酶家族的新成员。
• Kunitz domain polypeptide Zkun11
  申请人：——

  公开号：US20020111460A1

  公开（公告）日：2002-08-15

  Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part by protease inhibitors that comprise a Kunitz domain. Zkun11 is a new member of the Kunitz domain protein family.

  丝氨酸蛋白酶家族成员在血液凝固、纤维蛋白溶解、补体激活、受精和激素分泌等受严格控制的过程中发挥作用。丝氨酸蛋白酶的酶活性部分是由包含 Kunitz 结构域的蛋白酶抑制剂调节的。Zkun11 是 Kunitz 结构域蛋白家族的新成员。
• Human serine protease
  申请人：——

  公开号：US20020151029A1

  公开（公告）日：2002-10-17

  Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic, and industrial contexts. Zfaix1 is a new member of the serine protease family.

  丝氨酸蛋白酶家族的成员在血液凝固、纤维蛋白溶解、补体激活、受精和激素分泌等严格控制的过程中发挥作用。这些酶还被用于各种诊断、治疗和工业领域。Zfaix1 是丝氨酸蛋白酶家族的新成员。
• Lp mammalian proteins; related reagents
  申请人：——

  公开号：US20040266674A1

  公开（公告）日：2004-12-30

  Isolated nucleic acid molecules encoding polypeptides from a human, reagents related thereto (including purified polypeptides specific antibodies) are provided. Methods of using said reagents and diagnostic kits are also provided.

  提供了编码人类多肽的分离核酸分子、相关试剂（包括纯化的多肽特异性抗体）。还提供了使用所述试剂和诊断试剂盒的方法。