(1aS,7bR)-5-[[4-fluoro-2-[(E)-3-pyrrolidin-1-ylprop-1-enyl]phenyl]sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噁庚英
• 英文名称: (1aS,7bR)-5-[[4-fluoro-2-[(E)-3-pyrrolidin-1-ylprop-1-enyl]phenyl]sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid
• 化学式: C₂₄H₂₅FN₂O₅S
• 分子量: 472.5
• InChiKey: VSJGXPKALXORRY-HLPXUMPJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Partially Saturated Tricyclic Compounds and Methods of Making and Using Same
  申请人：Cramp Susan Mary

  公开号：US20140088078A1

  公开（公告）日：2014-03-27

  The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

  本发明提供了三环化合物及其在治疗医学疾病，如肥胖症中的应用。同时提供了制备各种三环化合物的药物组合物和方法。这些化合物被认为对甲硫氨酰基氨肽酶2具有活性。
• METHODS OF TREATING LIVER DISEASES
  申请人：ZAFGEN, INC.

  公开号：US20160058731A1

  公开（公告）日：2016-03-03

  The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.

  该发明提供了三环化合物及其在治疗肝脏疾病，如非酒精性脂肪性肝炎及相关疾病（例如纤维化）方面的用途。这些化合物被认为具有对甲硫氨酰基肽酶2的活性。
• Methods of treating liver diseases
  申请人：Zafgen, Inc.

  公开号：US10064839B2

  公开（公告）日：2018-09-04

  The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.

  本发明提供了三环化合物及其在治疗肝脏疾病，如非酒精性脂肪性肝炎和相关疾病（如纤维化）中的用途。这些化合物被认为具有对抗蛋氨酰氨基肽酶 2 的活性。
• Treatment for tumors driven by metabolic dysfunction
  申请人：SynDevRx, Inc.

  公开号：US10646463B2

  公开（公告）日：2020-05-12

  The present disclosure relates to modified or polymer conjugated MetAP2 inhibitors. The present disclosure also relates to methods of treating metabolically-driven diseases and disorders, such as certain cancers.

  本公开涉及修饰的或聚合物共轭的 MetAP2 抑制剂。本公开还涉及治疗代谢驱动的疾病和失调（如某些癌症）的方法。
• PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
  申请人：Zafgen, Inc.

  公开号：EP2705030B1

  公开（公告）日：2016-07-27