(E)-6-(tert-butyldimethylsilyloxy)-N-(2-hydroxyethyl)hex-2-enamide | 1197311-19-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (E)-6-(tert-butyldimethylsilyloxy)-N-(2-hydroxyethyl)hex-2-enamide
• 英文别名: (E)-6-[tert-butyl(dimethyl)silyl]oxy-N-(2-hydroxyethyl)hex-2-enamide
• CAS: 1197311-19-5
• 化学式: C₁₄H₂₉NO₃Si
• 分子量: 287.475
• InChiKey: WETNBKIPKQBMJG-VQHVLOKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.45
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  、 C.I.酸性橙108 在 potassium phosphate 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 (E)-6-(tert-butyldimethylsilyloxy)-N-(2-hydroxyethyl)hex-2-enamide
  参考文献：
  名称：

  Acryloyl Chloride: An Excellent Substrate for Cross-Metathesis. A One-Pot Sequence for the Synthesis of Substituted α,β-Unsaturated Carbonyl Derivatives

  摘要：

  A diverse set of functionalized alpha,beta-unsaturated carbonyl compounds were synthesized in good yield by utilizing a very simple one-pot process involving a cross-metathesis between acryloyl chloride and a terminal olefin followed by the addition of a nucleophile.

  DOI：

  10.1021/ol9021386

文献信息

• Acryloyl Chloride: An Excellent Substrate for Cross-Metathesis. A One-Pot Sequence for the Synthesis of Substituted α,β-Unsaturated Carbonyl Derivatives
  作者：Laurent Ferrié、Samir Bouzbouz、Janine Cossy

  DOI：10.1021/ol9021386

  日期：2009.12.3

  A diverse set of functionalized alpha,beta-unsaturated carbonyl compounds were synthesized in good yield by utilizing a very simple one-pot process involving a cross-metathesis between acryloyl chloride and a terminal olefin followed by the addition of a nucleophile.