[3,3,3-Trifluoro-2-[(2-hydroxy-1-phenylethyl)amino]-2-methylpropyl]carbamic acid

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [3,3,3-Trifluoro-2-[(2-hydroxy-1-phenylethyl)amino]-2-methylpropyl]carbamic acid
• 英文别名: [3,3,3-trifluoro-2-[(2-hydroxy-1-phenylethyl)amino]-2-methylpropyl]carbamic acid
• 化学式: C₁₃H₁₇F₃N₂O₃
• 分子量: 306.28
• InChiKey: IVFLZTMFAPQICD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  81.6
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20140128372A1

  公开（公告）日：2014-05-08

  The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及新型取代咪唑[1,2-a]吡啶-3-羧酰胺，其制备方法，单独或组合使用以治疗和/或预防疾病，以及用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• 3-(PYRIMIDINE-2-YL)IMIDAZO[1,2-A]PYRIDINES
  申请人：BAYER FHARMA AKTIENGESELLSCHAFT

  公开号：US20160347770A1

  公开（公告）日：2016-12-01

  The present application relates to novel 3-(pyrimidin-2-yl)imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及新颖的3-(嘧啶-2-基)咪唑并[1,2-a]吡啶，其制备方法，其单独或组合使用用于治疗和/或预防疾病，以及其用于生产药物治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
• SUBSTITUTED PYRAZOLO[1,5-A]-PYRIDINE-3-CARBOXAMIDES AND USE THEREOF
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160185775A1

  公开（公告）日：2016-06-30

  The present application relates to novel pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及新型吡唑并[1,5-a]吡啶-3-羧酰胺、其制备方法、其单独或与其他药物联合治疗和/或预防疾病的用途，以及其用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150274719A1

  公开（公告）日：2015-10-01

  The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及新型取代的咪唑并[1,2-a]吡啶-3-羧酰胺，其制备方法，其单独或与其他药物联合用于治疗和/或预防疾病，以及其用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• Amino-substituted imidazo[1,2-A] pyridinecarboxamides and their use
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US10662185B2

  公开（公告）日：2020-05-26

  The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides of the general formula (I) to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及通式 (I) 的新型取代咪唑并[1,2-a]吡啶-3-甲酰胺 它们的制备工艺，它们在治疗和/或预防疾病方面的单独用途或组合用途，以及它们在制备治疗和/或预防疾病（尤其是治疗和/或预防心血管疾病）的药物方面的用途。