1-(3-Fluoro-7-methoxy-1-benzothiophen-2-yl)ethanimine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 1-(3-Fluoro-7-methoxy-1-benzothiophen-2-yl)ethanimine
• 英文别名: 1-(3-fluoro-7-methoxy-1-benzothiophen-2-yl)ethanimine
• 化学式: C₁₁H₁₀FNOS
• 分子量: 223.27
• InChiKey: NXZXNORNXHBFCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  61.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE<br/>[FR] COMPOSÉS DE DIOXYDE DE THIADIAZINE SUBSTITUÉS TRICYCLIQUES EN TANT QU'INHIBITEURS DE BACE, COMPOSITIONS ET LEUR UTILISATION
  申请人：MERCK SHARP & DOHME

  公开号：WO2014062549A1

  公开（公告）日：2014-04-24

  In its many embodiments, the present invention provides provides certain iminothiazine dioxide compounds, including compounds Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein the middle ring (referred to herein as "ring B") of the tricyclic substituent is an optionally substituted 5-membered ring, and each of the remaining variables shown in the formula are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including Alzheimer's disease, are also disclosed.

  在其多种实施方式中，本发明提供了某些亚噻唑二氧化物化合物，包括化合物式（I）：及其互变异构体和立体异构体，以及所述化合物的药学上可接受的盐，所述互变异构体和所述立体异构体，其中三环取代基的中间环（以下简称为“环B”）是一个可选择取代的5-成员环，并且所示公式中的其余各变量如本文所定义。本发明的新化合物可用作BACE抑制剂和/或用于治疗和预防与之相关的各种病理。还公开了包括一种或多种此类化合物（单独和与一种或多种其他活性剂组合）的药物组合物，以及其制备和使用方法，包括治疗阿尔茨海默病。