(5E)-5-hydroxyimino-1,3,3-trimethylcyclohexane-1-carbonitrile

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (5E)-5-hydroxyimino-1,3,3-trimethylcyclohexane-1-carbonitrile
• 化学式: C₁₀H₁₆N₂O
• 分子量: 180.25
• InChiKey: HKGGDIPODJYTOY-XYOKQWHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  56.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 3-AMINOMETHYL-3, 5, 5-TRIMETHYL CYCLOHEXYLAMINE PREPARATION METHOD
  申请人：Chen Changsheng

  公开号：US20140142341A1

  公开（公告）日：2014-05-22

  Provided is a 3-aminomethyl-3,5,5-trimethylcyclohexylamine preparation method. A feeding flow of 3-cyano-3,5,5-trimethylcyclohexylimine is reacted with NH3 and hydrogen in the presence of a hydrogenation catalyst; the method is characterized by: firstly adding a basic compound to the feeding flow of 3-cyano-3,5,5-trimethylcyclohexylimine, and then after a portion of 3-cyano-3,5,5-trimethylcyclohexylimine has reacted, adding an acidic compound to reaction materials for further hydrogenation reaction to prepare the product. The method ensures that the aminonitrile content in the product is low, thus effectively reducing the duration of the reaction and greatly reducing the consumption of the catalyst during the hydrogenation reaction process.

  提供了一种3-氨甲基-3,5,5-三甲基环己基胺的制备方法。将3-氰基-3,5,5-三甲基环己基亚胺的进料流与氢气和NH3在氢化催化剂的存在下反应；该方法的特点是：首先向3-氰基-3,5,5-三甲基环己基亚胺的进料流中加入一种碱性化合物，然后在部分3-氰基-3,5,5-三甲基环己基亚胺反应后，向反应物中加入一种酸性化合物进行进一步的氢化反应以制备产物。该方法确保了产物中的氨基腈含量较低，从而有效缩短了反应时间，并在氢化反应过程中大大降低了催化剂的消耗。