carbamic acid;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: carbamic acid;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
• 化学式: C21H25N9O7
• 分子量: 515.5
• InChiKey: VGJYGJXOCZTYEB-ZOWNYOTGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.11
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  274
• 氢给体数：
  7
• 氢受体数：
  14

文献信息

• [EN] COMPOSITIONS AND METHODS FOR CAPTURE OF CELLULAR TARGETS OF BIOACTIVE AGENTS<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE CAPTURE DE CIBLES CELLULAIRES D'AGENTS BIOACTIFS
  申请人：PROMEGA CORP

  公开号：WO2014093671A1

  公开（公告）日：2014-06-19

  The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture fusions), surfaces (e.g., displaying, capture ligands, capture proteins, or capture fusions), and methods of capturing and identifying the cellular targets of a bioactive agent therewith.

  本发明提供了一种用于捕获和识别生物活性剂的细胞靶标的组合物和方法。具体来说，本文提供了与捕获配体、细胞靶标（可选择性地标记有报告物）、捕获蛋白（可选择性地作为捕获融合物存在）、表面（例如，显示捕获配体、捕获蛋白或捕获融合物）以及用于捕获和识别生物活性剂的细胞靶标的方法。
• COMPOSITIONS AND METHODS FOR CAPTURE OF CELLULAR TARGETS OF BIOACTIVE AGENTS
  申请人：Promega Corporation

  公开号：US20140287427A1

  公开（公告）日：2014-09-25

  The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture dimers), surfaces (e.g., displaying, capture ligands, capture proteins, or capture dimers), and methods of capturing and identifying the cellular targets of a bioactive agent therewith.

  本发明提供了一种捕获和鉴定生物活性剂的细胞靶标的组合物和方法。具体来说，本发明提供了通过捕获配体连接的生物活性剂、细胞靶标（可选择性地带有报告基团）、捕获蛋白（可选择性地存在为捕获二聚体）、表面（例如，展示捕获配体、捕获蛋白或捕获二聚体）以及用于捕获和鉴定生物活性剂的细胞靶标的方法。
• SUBSTRATES FOR COVALENT TETHERING OF PROTEINS TO FUNCTIONAL GROUPS OR SOLID SURFACES
  申请人：PROMEGA CORPORATION

  公开号：US20140322794A1

  公开（公告）日：2014-10-30

  The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.

  本发明提供了卤代烷基底物和连接这种底物与功能元件（例如标签、标记、表面等）的连接物。本文所描述的底物和连接物可用于蛋白质、细胞和分子的标记、检测和固定等方面。特别是，本发明提供的连接物可用于卤代烷酶变体的底物中，这些变体与其卤代烷基底物形成共价键。
• Compositions and methods for capture of cellular targets of bioactive agents
  申请人：Promega Corporation

  公开号：US10168323B2

  公开（公告）日：2019-01-01

  The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture dimers), surfaces (e.g., displaying, capture ligands, capture proteins, or capture dimers), and methods of capturing and identifying the cellular targets of a bioactive agent therewith.

  本发明提供了用于捕获和鉴定生物活性剂细胞靶标的组合物和方法。特别是，本发明提供了与捕获配体、细胞靶标（可选择标记报告物）、捕获蛋白（可选择以捕获二聚体形式存在）、表面（如显示、捕获配体、捕获蛋白或捕获二聚体）相连的生物活性剂，以及用其捕获和识别生物活性剂的细胞靶标的方法。
• Substrates for covalent tethering of proteins to functional groups or solid surfaces
  申请人：PROMEGA CORPORATION

  公开号：US11072812B2

  公开（公告）日：2021-07-27

  The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.

  本发明提供了卤代烃基底以及用于将此类基底与功能元件（如标签、标记、表面等）连接的连接体。本文所述的底物和连接体可用于蛋白质、细胞和分子的标记、检测和固定等。特别是，本文提供的连接体可用于与卤代烃底物形成共价键的脱卤酶变体的底物中。