N'-ethyl-N-[(Z)-prop-1-enyl]methanimidamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N'-ethyl-N-[(Z)-prop-1-enyl]methanimidamide
• 化学式: C₆H₁₂N₂
• 分子量: 112.17
• InChiKey: YPHCQPMZGRZDCJ-HYXAFXHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] PRMT5 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE PRMT5 ET LEURS UTILISATIONS
  申请人：EPIZYME INC

  公开号：WO2014100695A1

  公开（公告）日：2014-06-26

  Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

  本文描述了式（A）的化合物，其药学上可接受的盐以及药物组合物。本发明的化合物对抑制PRMT5活性是有用的。还描述了利用这些化合物治疗PRMT5介导的疾病的方法。
• [EN] QUINOLINE COMPOUNDS AS FUNGICIDES<br/>[FR] COMPOSÉS DE QUINOLÉINE EN TANT QUE FONGICIDES
  申请人：BASF SE

  公开号：WO2018073110A1

  公开（公告）日：2018-04-26

  The present invention relates to compounds I, wherein the variables are defined as given in the description and claims. The invention further relates to uses, processes and intermediates for compounds I.

  本发明涉及化合物I，其中变量如描述和权利要求所示。本发明还涉及化合物I的用途、工艺和中间体。
• [EN] METHODS OF INHIBITING PRMT5<br/>[FR] PROCÉDÉS D'INHIBITION DE PRMT5
  申请人：EPIZYME INC

  公开号：WO2014100764A2

  公开（公告）日：2014-06-26

  Described herein are compounds of Formula (I) useful for inhibiting PRMT5 activity. The planes of Ring AA and Ring BB are between 75° and 105°. Ring AA-M-Ring BB (I)
• [EN] PYRIDINE COMPOUNDS FOR CONTROLLING PHYTOPATHOGENIC HARMFUL FUNGI<br/>[FR] COMPOSÉS DE PYRIDINE POUR LUTTER CONTRE DES CHAMPIGNONS NOCIFS PHYTOPATHOGÈNES
  申请人：BASF SE

  公开号：WO2018054723A1

  公开（公告）日：2018-03-29

  The present invention relates to compounds of formula (I) wherein the variables are defined as given in the description and claims. The invention further relates to uses and composition for compounds of formula I.
• [EN] OPTIMIZED NUCLEOTIDE SEQUENCES ENCODING SARS-COV-2 ANTIGENS<br/>[FR] SÉQUENCES NUCLÉOTIDIQUES OPTIMISÉES CODANT POUR DES ANTIGÈNES DU SRAS-COV-2
  申请人：[en]TRANSLATE BIO, INC.

  公开号：WO2021226436A1

  公开（公告）日：2021-11-11

  The present invention relates to optimized nucleotide sequence encoding SARS-CoV-2 antigens. These sequences are particularly suitable for use in vaccine compositions for the treatment or prevention of infections caused by a β-coronaviruses, including COVID-19 infections, in a human or animal subject in need of such treatment.