3-(5-Methyl-4-oxo-3-phenylquinazolin-2-yl)propylcarbamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(5-Methyl-4-oxo-3-phenylquinazolin-2-yl)propylcarbamic acid
• 英文别名: 3-(5-methyl-4-oxo-3-phenylquinazolin-2-yl)propylcarbamic acid
• 化学式: C₁₉H₁₉N₃O₃
• 分子量: 337.4
• InChiKey: OXUJYQZBNHBNGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  82
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS SUBSTITUÉS D'AMINOPYRIMIDINE ET PROCÉDÉS D'UTILISATION
  申请人：CALITOR SCIENCES LLC

  公开号：WO2015042077A1

  公开（公告）日：2015-03-26

  The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukernias and solid tumors, in mammals, especially humans.

  本发明涉及新的氨基嘧啶衍生物的制备和应用，作为自由形式或药物可接受的盐形式和制剂的药物候选物，用于调节由PI3K酶活性介导的疾病或疾病。本发明还提供了包含这种化合物的药物可接受的组合物和使用这些组合物治疗疾病或疾病的方法，例如，PI3K酶在白细胞功能中发挥作用的免疫和炎症疾病，以及与PI3K活性相关的高增殖性疾病，包括但不限于哺乳动物，特别是人类的白血病和实体肿瘤。
• SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
  申请人：Calitor Sciences, LLC

  公开号：EP3046563A1

  公开（公告）日：2016-07-27
• [EN] SUBSTITUTED 2-AMINO PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIMIDINE À SUBSTITUTION 2-AMINO SERVANT DE COMPOSÉS INHIBITEURS DE KINASE
  申请人：AURIGENE DISCOVERY TECH LTD

  公开号：WO2014106800A2

  公开（公告）日：2014-07-10

  The present invention provides novel substituted 2-amino pyrimidine derivatives kinase enzyme inhibitor compounds of formula (1), which may be therapeutically useful kinase inhibitor, more particularly PI3K inhibitors. Formula (1) in which A, R1, R2 R3. R4, Q and 'n' have the same meanings given in the specification, and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting kinase enzyme, more particularly PI3K enzyme. The present invention also provides methods for synthesizing and administering the kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.