(3aR,7R,7aS)-tert-butyl 5-(3-aminopyridin-4-yl)-7-methyl-2-oxohexahydrooxazolo[4,5-c]pyridine-3(2H)-carboxylate | 1187056-34-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3aR,7R,7aS)-tert-butyl 5-(3-aminopyridin-4-yl)-7-methyl-2-oxohexahydrooxazolo[4,5-c]pyridine-3(2H)-carboxylate
• 英文别名: (3aR,7R,7aS)-tert-butyl 5-(3-aminopyridin-4-yl)-7-methyl-2-oxohexahydrooxazolo[4,5-c]pyridine-3-carboxylate；(3aR,7R,7aS)-tert-butyl 5-(3-aminopyridin-4-yl)-7-methyl-2-oxohexahydrooxazolo[4,5-c]pyridin-3-carboxylate；tert-butyl (3aR,7R,7aS)-5-(3-aminopyridin-4-yl)-7-methyl-2-oxo-4,6,7,7a-tetrahydro-3aH-[1,3]oxazolo[4,5-c]pyridine-3-carboxylate
• CAS: 1187056-34-3
• 化学式: C₁₇H₂₄N₄O₄
• 分子量: 348.402
• InChiKey: QIKSVUPVGNHSFW-HONMWMINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  98
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (3aR,7R,7aS)-tert-butyl 7-methyl-5-(3-nitropyridin-4-yl)-2-oxohexahydrooxazolo[4,5-c]pyridine-3(2H)-carboxylate 在 钯 甲醇 作用下， 以 甲醇 为溶剂， 反应 14.0h， 以yielding (3aR,7R,7aS)-tert-butyl 5-(3-aminopyridin-4-yl)-7-methyl-2-oxohexahydrooxazolo[4,5-c]pyridine-3(2H)-carboxylate的产率得到(3aR,7R,7aS)-tert-butyl 5-(3-aminopyridin-4-yl)-7-methyl-2-oxohexahydrooxazolo[4,5-c]pyridine-3(2H)-carboxylate
  参考文献：
  名称：

  PIM KINASE INHIBITORS AND METHODS OF THEIR USE

  摘要：

  本发明涉及公式I和II的新化合物，它们的互变异构体、立体异构体和多晶形式，以及其药学上可接受的盐、酯、代谢产物或前药，新化合物与药学上可接受的载体的组成物，以及新化合物的用途，单独或与至少一种额外的治疗剂联合使用，用于抑制Pim激酶活性和/或预防或治疗癌症。

  公开号：

  US20120202851A1

文献信息

• [EN] PIM KINASE INHIBITORS AND METHODS OF THEIR USE<br/>[FR] INHIBITEURS DE PIM KINASE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：NOVARTIS AG

  公开号：WO2009109576A1

  公开（公告）日：2009-09-11

  The present invention relates to new compounds of Formulas (I) and (II), their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pirn kinase activity and/or the prophylaxis or treatment of cancer.

  本发明涉及公式（I）和（II）的新化合物，它们的互变异构体、立体异构体和多型体，以及其药学上可接受的盐、酯、代谢物或前药，新化合物与药学上可接受的载体的组合物，以及新化合物的用途，单独或与至少一种额外治疗剂联合使用，用于抑制Pirn激酶活性和/或预防或治疗癌症。
• Pim kinase inhibitors and methods of their use
  申请人：Burger Matthew

  公开号：US20100216839A1

  公开（公告）日：2010-08-26

  The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pim kinase activity and/or the prophylaxis or treatment of cancer.

  本发明涉及公式I和II的新化合物，它们的互变异构体、立体异构体和多晶形态，以及其药学上可接受的盐、酯、代谢物或前药，新化合物与药学上可接受的载体的组合物，以及新化合物的用途，单独或与至少一种额外治疗剂联合使用，在抑制Pim激酶活性和/或预防或治疗癌症方面。
• PIM KINASE INHIBITORS AND METHODS OF THEIR USE
  申请人：Burger Matthew

  公开号：US20120202851A1

  公开（公告）日：2012-08-09

  The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pim kinase activity and/or the prophylaxis or treatment of cancer.

  本发明涉及公式I和II的新化合物，它们的互变异构体、立体异构体和多晶形式，以及其药学上可接受的盐、酯、代谢产物或前药，新化合物与药学上可接受的载体的组成物，以及新化合物的用途，单独或与至少一种额外的治疗剂联合使用，用于抑制Pim激酶活性和/或预防或治疗癌症。
• KINASE INHIBITORS AND METHODS OF THEIR USE
  申请人：Burger Matthew T.

  公开号：US20120134987A1

  公开（公告）日：2012-05-31

  New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.

  本发明提供了用于抑制与人类或动物主体中肿瘤发生相关的Provirus Integration of Maloney Kinase（PIM激酶）活性的新化合物，组合物和方法。在某些实施例中，这些化合物和组合物有效地抑制至少一种PIM激酶的活性。这些新的化合物和组合物可以单独使用或与至少一种其他药物联合使用，用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的疾病，如癌症。
• PIM kinase inhibitors and methods of their use
  申请人：Burger Matthew

  公开号：US08829193B2

  公开（公告）日：2014-09-09

  The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pim kinase activity and/or the prophylaxis or treatment of cancer.

  本发明涉及公式I和II的新化合物，它们的互变异构体、立体异构体和多晶形式，以及其药学上可接受的盐、酯、代谢物或前药。还涉及含有这些新化合物和药学上可接受的载体的组合物，以及这些新化合物的用途，单独使用或与至少一种其他治疗剂联合使用，用于抑制Pim激酶活性和/或预防或治疗癌症。