4-[[4-cyclopentyloxy-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-hydroxy-N-methylbenzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 4-[[4-cyclopentyloxy-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-hydroxy-N-methylbenzamide
• 化学式: C₂₇H₂₆N₆O₄
• 分子量: 498.5
• InChiKey: YSXNDQXZPZJRNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  138
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• [EN] SUBSTITUTED PYRROLOPYRIMIDINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH<br/>[FR] COMPOSÉS DE TYPE PYRROLOPYRIMIDINE SUBSTITUÉE, COMPOSITIONS EN CONTENANT ET MÉTHODES DE TRAITEMENT FAISANT APPEL À EUX
  申请人：SIGNAL PHARM LLC

  公开号：WO2014113429A2

  公开（公告）日：2014-07-24

  Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.
• [EN] AMORPHOUS FORM OF 4-((4(CYCLOPENTYLOXY)-5-(2-METHYLBENZO[D]OXAZOL-6-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)AMINO)-3-METHOXY-N-METHYLBENZAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE<br/>[FR] FORME AMORPHE DE 4- ((4 (CYCLOPENTYLOXY) -5-METHYLBENZO[D]OXAZOL-6-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)AMINO)-3-METHOXY-N-METHYLBENZAMIDE, COMPOSITIONS CONTENANT UNE TELLE FORME ET LEURS PROCEDES D'UTILISATION
  申请人：SIGNAL PHARM LLC

  公开号：WO2016010887A1

  公开（公告）日：2016-01-21

  Provided herein is an amorphous form of 4-((4-(Cyclopentyloxy)-5-(2-methylbenzo [d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide, compositions thereof, and methods of their use for treating or preventing a cancer, in particular solid tumors and hematological cancers as described herein.
• [EN] SOLOD FORMS 4-((4-(CYCLOPENTYLOXY)-5-(2-METHYLBENZO[D] OXAZOL-6-YL)17H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)AMINO)-3-METHOXY-N-METHYLBENZAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE<br/>[FR] 4-((4(CYCLOPENTYLOXY)-5-MÉTHYLBENZO[D]OXAZOL-6-YL)-17H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)AMINO)-3-MÉTHOXY-N-MÉTHYLBENZAMIDE SOUS FORME SOLIDE, COMPOSITIONS CORRESPONDANTES ET PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：SIGNAL PHARM LLC

  公开号：WO2017011720A1

  公开（公告）日：2017-01-19

  Provided herein are solid forms of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6- yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide, compositions thereof, and methods of their use for treating or preventing a cancer, in particular solid tumors and hematological cancers as described herein.