(1Z)-cycloocten-1-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1Z)-cycloocten-1-amine
• 化学式: C₈H₁₅N
• 分子量: 125.21
• InChiKey: ZHIJPZFDZXWCGV-VURMDHGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• TETRAZINES/TRANS-CYCLOOCTENES IN SOLID PHASE SYNTHESIS OF LABELED PEPTIDES
  申请人：MEMORIAL SLOAN-KETTERING CANCER CENTER

  公开号：US20150359913A1

  公开（公告）日：2015-12-17

  This invention is in the field of labeled peptide construction for medical treatment and analysis. The invention relates to synthetic labeled peptide compositions, methods of synthesis, and methods of use for the synthetic labeled peptide compositions for medical treatment, imaging, and research purposes.

  这项发明涉及用于医疗治疗和分析的标记肽构建领域。该发明涉及合成标记肽组合物、合成方法以及用于医疗治疗、成像和研究目的的合成标记肽组合物的使用方法。
• BIOINK FOR REVERSIBLY FORMING A HYDROGEL BY LIGHT
  申请人：Albert-Ludwigs-Universität Freiburg

  公开号：EP3919091A1

  公开（公告）日：2021-12-08

  The present bioink comprises a first polymer coupled to a first protein and a second polymer coupled to a second protein, wherein the first protein and the second protein form a heterodimer upon irradiation with visible or infrared light in a specific wavelength range, which can be reversed upon irradiating the heterodimer with visible or infrared light in a second wavelength range, wherein the second wavelength range is different from the first wavelength range. The bioink enables a quick and reversible formation of hydrogels using cell-friendly light.

  本生物墨水包括与第一蛋白质偶联的第一聚合物和与第二蛋白质偶联的第二聚合物，其中第一蛋白质和第二蛋白质在特定波长范围的可见光或红外光照射下形成异二聚体，在第二波长范围的可见光或红外光照射异二聚体时可逆转异二聚体，其中第二波长范围不同于第一波长范围。这种生物墨水能利用细胞友好光快速、可逆地形成水凝胶。
• Two-component bioink, 3D biomaterial comprising the same and method for preparing the same
  申请人：AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US10894895B2

  公开（公告）日：2021-01-19

  The present invention provides a two-component bioink including a first solution and a second solution separately, wherein (i) the first solution includes a first biopolymer to which a first chemical functional group is introduced, and the second solution includes a second biopolymer to which a second chemical functional group able to chemically bond with the first chemical functional group is introduced; or (ii) the first solution includes a third biopolymer having a first electrostatic functional group, and the second solution includes a fourth biopolymer having a second electrostatic functional group able to physically bond with the first electrostatic functional group, a 3D biomaterial including the same, and a method for preparing the same.

  本发明提供了一种双组分生物墨水，分别包括第一溶液和第二溶液，其中(i)第一溶液包括第一种生物聚合物，其中引入了第一化学官能团，第二溶液包括第二种生物聚合物，其中引入了能够与第一化学官能团化学键合的第二化学官能团；或 (ii) 第一种溶液包括具有第一静电官能团的第三种生物聚合物，第二种溶液包括具有能与第一静电官能团发生物理键合的第二静电官能团的第四种生物聚合物，包括上述第一种溶液和第二种溶液的三维生物材料，以及制备上述第一种溶液和第二种溶液的方法。
• Drug delivery formulation for treating mental illness or central nervous system disorder
  申请人：AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US11337929B2

  公开（公告）日：2022-05-24

  A drug delivery formulation for treating a mental illness or a central nervous system disorder is disclosed. The drug delivery formulation includes a microcapsule containing a biodegradable polymer and a drug and a crosslinked hydrogel and a method for preparing the same. The drug delivery formulation can slowly release a drug at a constant rate without a burst of drug release in the early stage of drug administration to maintain a constant blood drug level over a long period of time and thus enjoys the advantage of preventing excessive initial release of drug, thereby obtaining a desirable sustained release profile by single administration without necessity for multiple administrations divided at regular time intervals.

  本发明公开了一种用于治疗精神疾病或中枢神经系统疾病的给药配方。该给药配方包括含有生物可降解聚合物和药物的微胶囊以及交联水凝胶及其制备方法。该给药配方能以恒定的速率缓慢释放药物，而不会在给药初期出现药物猝发释放，从而在较长时间内保持恒定的血药浓度，因此具有防止药物初始释放过多的优点，从而通过单次给药获得理想的持续释放曲线，而无需按固定时间间隔多次给药。
• TWO-COMPONENT BIOINK, 3D BIOMATERIAL COMPRISING THE SAME AND METHOD FOR PREPARING THE SAME
  申请人：Ajou University Industry-Academic Cooperation Foundation

  公开号：EP3313944A1

  公开（公告）日：2018-05-02