ethyl-hexadecyl-[(N'-hexadecylcarbamimidoyl)amino]-methylazanium;chloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: ethyl-hexadecyl-[(N'-hexadecylcarbamimidoyl)amino]-methylazanium;chloride
• 化学式: C36H77ClN4
• 分子量: 601.5
• InChiKey: MOFGPMTXKIEUBX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  8.24
• 重原子数：
  41
• 可旋转键数：
  33
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Method for inhibiting tumor growth through RNA-interference using liposomally associated CDC20 siRNA
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US10227589B2

  公开（公告）日：2019-03-12

  Liposomal compositions comprising of liposomes of guanidinylated cationic amphiphiles as the main lipid and cholesterol/1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/aminopropyl polyethyleneglycol carbamyl-distearoylphosphatidyl-ethanolamine (DSPE-peg-NH2) as co-lipids are described. These liposomal compositions containing encapsulated or electrostatically complexed therapeutic small interfering RNAs (siRNAs) against Cdc20, a key cell cycle regulator, inhibit solid tumor growth and melanoma tumor growth on lung in C57BL/6J mice.

  本研究描述了由胍基阳离子两性化合物脂质体作为主脂质和胆固醇/1,2-二油酰-sn-甘油-3-磷脂酰胆碱（DOPC）/氨基丙基聚乙二醇氨基甲酰-二硬脂酰磷脂酰乙醇胺（DSPE-peg-NH2）作为辅脂质组成的脂质体组合物。这些脂质体组合物含有针对细胞周期关键调节因子 Cdc20 的包封或静电络合治疗性小干扰 RNA（siRNA），可抑制 C57BL/6J 小鼠肺部实体瘤和黑色素瘤的生长。
• METHOD FOR INHIBITING TUMOR GROWTH THROUGH RNA-INTERFERENCE USING LIPOSOMALLY ASSOCIATED CDC20 siRNA
  申请人：Council of Scientific & Industrial Research

  公开号：EP2948550A1

  公开（公告）日：2015-12-02
• [EN] METHOD FOR INHIBITING TUMOR GROWTH THROUGH RNA-INTERFERENCE USING LIPOSOMALLY ASSOCIATED CDC20 siRNA<br/>[FR] MÉTHODE D'INHIBITION DE LA CROISSANCE DE TUMEUR PAR INTERFÉRENCE ARN AU MOYEN D'ARNsi CDC20 ASSOCIÉ À DES LIPOSOMES
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2014115158A1

  公开（公告）日：2014-07-31

  Liposomal compositions comprising of liposomes of guanidinylated cationic amphiphiles as the main lipid and cholesterol/1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/aminopropyl polyethyleneglycol carbamyl-distearoylphosphatidyl-ethanolamine (DSPE-peg-NH2) as co-lipids are described. These liposomal compositions containing encapsulated or electrostatically complexed therapeutic small interfering RNAs (siRNAs) against Cdc20, a key cell cycle regulator, inhibit solid tumor growth and melanoma tumor growth on lung in C57BL/6J mice.