N,2,3,4,5,6-hexamethylideneoctanamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,2,3,4,5,6-hexamethylideneoctanamide
• 化学式: C₁₄H₁₇NO
• 分子量: 215.29
• InChiKey: CZTVGEUDRZUOAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.4
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Aqueous ophthalmic solutions of phentolamine and medical uses thereof
  申请人：Ocuphire Pharma, Inc.

  公开号：US10278918B2

  公开（公告）日：2019-05-07

  The invention provides aqueous ophthalmic solutions of phentolamine or pharmaceutically acceptable salts thereof, medical kits, and methods for using such ophthalmic solutions to improve visual performance in a patient. Exemplary aqueous ophthalmic solutions include those containing phentolamine mesylate, mannitol, sodium acetate, and water.

  本发明提供了酚妥拉明或其药学上可接受的盐类的眼科水溶液、医疗包以及使用此类眼科溶液改善患者视力的方法。示例性眼科水溶液包括含有甲磺酸酚妥拉明、甘露醇、醋酸钠和水的眼科水溶液。
• Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders
  申请人：Ocuphire Pharma, Inc.

  公开号：US10993932B2

  公开（公告）日：2021-05-04

  The invention provides methods, compositions, and kits containing an alpha-adrenergic antagonist, such as phentolamine, for use in monotherapy or as part of a combination therapy to treat patients suffering from presbyopia, mydriasis, and/or other ocular disorders.

  本发明提供了含有α-肾上腺素能拮抗剂（如酚妥拉明）的方法、组合物和试剂盒，用于单药治疗或作为联合疗法的一部分，治疗患有老花眼、近视和/或其他眼部疾病的患者。
• Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
  申请人：Ocuphire Pharma, Inc.

  公开号：US11000509B2

  公开（公告）日：2021-05-11

  The invention provides methods, compositions, and kits containing phentolamine for improving visual performance. In particular, the invention provides improvement in visual performance, such as improvement in visual acuity, by daily ophthalmic administration of a phentolamine solution to an eye of a patient at or near the bedtime of the patient for an extended duration while minimizing the occurrence of adverse side effects, such as eye redness during the patient's waking hours.

  本发明提供了含有酚妥拉明的用于改善视力的方法、组合物和试剂盒。特别是，本发明提供了通过每天在患者睡前或临近睡前对患者的眼睛进行长时间的酚妥拉明溶液眼科给药，同时最大限度地减少不良副作用的发生，如在患者清醒时眼睛发红，从而改善视觉表现，如改善视力。
• METHODS AND COMPOSITIONS FOR DAILY OPHTHALMIC ADMINISTRATION OF PHENTOLAMINE TO IMPROVE VISUAL PERFORMANCE
  申请人：Ocularis Pharma, LLC

  公开号：EP2950800A1

  公开（公告）日：2015-12-09
• AQUEOUS OPHTHALMIC SOLUTIONS OF PHENTOLAMINE AND MEDICAL USES THEREOF
  申请人：Ocularis Pharma, LLC

  公开号：EP2950648A1

  公开（公告）日：2015-12-09