5-chlorobenzothiophene-2-acetic acid | 23799-65-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 5-chlorobenzothiophene-2-acetic acid
• 英文别名: 2-(5-chloro-1-benzothiophen-2-yl)acetic acid
• CAS: 23799-65-7
• 化学式: C₁₀H₇ClO₂S
• 分子量: 226.683
• InChiKey: LGAPNNJIUFULJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[2-(3,5-二氟苯基)乙酰基]-L-丙氨酸 、 methyl 2-amino-2-(5-chlorobenzothiophen-2-yl)acetate 、 5-chlorobenzothiophene-2-acetic acid 生成 N-[N-(3,5-difluorophenylacetyl)-L-alaninyl]-2-amino-2-(5-chlorobenzothiophen-2-yl)acetate methyl ester
  参考文献：
  名称：

  Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis

  摘要：

  本发明涉及一种抑制β-淀粉样肽释放和/或合成的化合物，因此在治疗阿尔茨海默病方面具有用途。本发明还涉及包含抑制β-淀粉样肽释放和/或合成的化合物的制药组合物，以及使用这种制药组合物预防和治疗阿尔茨海默病的方法。

  公开号：

  US06888022B2

文献信息

• Compounds for inhibiting &bgr;-amyloid peptide release and/or its synthesis
  申请人：Elan Pharmaceuticals, Inc.

  公开号：US06211235B1

  公开（公告）日：2001-04-03

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis.

  揭示了一种抑制β-淀粉样肽释放和/或其合成的化合物，因此在治疗阿尔茨海默病方面具有用途。还揭示了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物。
• Methods and compounds for inhibiting &bgr;-amyloid peptide release and/or its synthesis
  申请人：Elan Pharmaceuticals, Inc.

  公开号：US06191166B1

  公开（公告）日：2001-02-20

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  揭示了一种抑制β-淀粉样肽释放和/或合成的化合物，因此在治疗阿尔茨海默病方面具有用途。还揭示了包括抑制β-淀粉样肽释放和/或合成的化合物的药物组合物，以及使用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
• Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
  申请人：Audia James E.

  公开号：US06861558B2

  公开（公告）日：2005-03-01

  Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明公开了一种抑制β-淀粉样肽释放和/或其合成的化合物，因此在治疗阿尔茨海默病方面具有用途。还公开了包括抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这种药物组合物预防和治疗阿尔茨海默病的方法。
• Heterocyclic acetic acid compounds and compositions for treating bone diseases
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0068563A2

  公开（公告）日：1983-01-05

  Certain acetic acid derivatives of benzothiophene, benzimidazole, phenothiazine, benzofuran, dibenzothiophene. and similar heterocyclic compounds have been found to inhibit bone resorption and to enhance bone formation. The compounds of this invention are therefore useful in the treatment of diseases characterized by anomalous bone metabolism.

  已发现苯并噻吩、苯并咪唑、吩噻嗪、苯并呋喃、二苯并噻吩和类似杂环化合物的某些乙酸衍生物可抑制骨吸收和促进骨形成。因此，本发明的化合物可用于治疗以骨代谢异常为特征的疾病。
• METHODS AND COMPOUNDS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS
  申请人：Elan Pharmaceuticals, Inc.

  公开号：EP0942924A2

  公开（公告）日：1999-09-22