(8R,9S,10R,13S,14S)-10,13-dimethyl-3,4,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (8R,9S,10R,13S,14S)-10,13-dimethyl-3,4,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-one
• 化学式: C₁₉H₂₆O
• 分子量: 270.4
• InChiKey: YBGJIPJBODSUCF-QAGGRKNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] RECEPTOR AND KINASE MODULATOR SCREENING METHODS<br/>[FR] PROCÉDÉS DE DÉPISTAGE DE RÉCEPTEUR ET DE MODULATEUR DE KINASE
  申请人：HARBOR THERAPEUTICS INC

  公开号：WO2014137420A1

  公开（公告）日：2014-09-12

  The invention provides methods to identify low toxicity modulators of mitogen- activated protein kinases, particularly MAPK1 and MAPK3. Such modulators are useful to treat hyperproliferation conditions including cancers such as prostate cancer, breast cancer, liver cancer and colon cancer. Such treatments are accompanied by reduced levels of toxicity, e.g., elevated liver enzymes, which are associated with ATP binding- site-dependent MAPK inhibitors.