(2E)-N-(methylideneamino)penta-2,4-dien-2-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2E)-N-(methylideneamino)penta-2,4-dien-2-amine
• 化学式: C₆H₁₀N₂
• 分子量: 110.16
• InChiKey: ZNGPNCJMPWKESM-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2964221B1

  公开（公告）日：2017-12-06
• ALKYNYL ALCOHOLS AND METHODS OF USE
  申请人：Genentech, Inc.

  公开号：US20170145034A1

  公开（公告）日：2017-05-25

  The invention relates to compounds of Formula (0): wherein Q, A 1 -A 8 , R 4 and R 5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
• US9605005B2
  申请人：——

  公开号：US9605005B2

  公开（公告）日：2017-03-28
• US9738638B2
  申请人：——

  公开号：US9738638B2

  公开（公告）日：2017-08-22
• [EN] COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY<br/>[FR] COMPOSÉS INHIBANT L'ACTIVITÉ ENZYMATIQUE DE LA KINASE À RÉPÉTITION RICHE EN LEUCINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2014137728A1

  公开（公告）日：2014-09-12

  The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.