4-Hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-Hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol
• 英文别名: 3-[2-[(2,2-dimethyl-3-sulfanylpropyl)-hexadecylamino]ethylamino]-2,2-dimethylpropane-1-thiol
• 化学式: C₂₈H₆₀N₂S₂
• 分子量: 488.9
• InChiKey: HZACQENNBBMTGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  32
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Compositions and associated methods for radioisotope-binding microparticles
  申请人：Biosphere Medical, Inc.

  公开号：US10434200B2

  公开（公告）日：2019-10-08

  The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.

  本公开涉及可以用放射性同位素标记的聚合材料、标记聚合材料的生产工艺以及在分析和治疗应用中使用这些材料的方法。具体而言，本公开涉及可注射和植入的微颗粒，如微球，这些微颗粒与放射性同位素相关联，从而使微颗粒既可治疗又可检测。含放射性同位素的微颗粒可用于栓塞和其他治疗性医疗应用。
• Imageable polymers, methods of making and methods of use thereof
  申请人：The United States of America, as Represented by the Secretary, Department of Health and Human Services

  公开号：US11382990B2

  公开（公告）日：2022-07-12

  Described herein are X-ray imageable polymers such as polymeric particles comprising bismuth as a radiopacifying agent, methods of making the polymers, and methods of using the polymers. The imageable particles may comprise a covalently bound compound which chelates the bismuth, for example, through a combination of nitrogen and oxygen atoms.

  本文描述的是 X 射线可成像聚合物，如包含铋作为放射增白剂的聚合物颗粒、制 造这种聚合物的方法以及使用这种聚合物的方法。可成像颗粒可包括一种共价结合的化合物，例如通过氮原子和氧原子的结合来螯合铋。
• COMPOSITIONS AND ASSOCIATED METHODS FOR RADIOISOTOPE-BINDING MICROPARTICLES
  申请人：Biosphere Medical Inc.

  公开号：EP2968165A1

  公开（公告）日：2016-01-20
• US20140271461A1
  申请人：——

  公开号：US20140271461A1

  公开（公告）日：2014-09-18
• Imageable Polymers, Methods of Making and Methods of Use Thereof
  申请人：The United States of America, as Represented by the Secretary, Department of Health Service

  公开号：US20200197540A1

  公开（公告）日：2020-06-25

  Described herein are X-ray imageable polymers such as polymeric particles comprising bismuth as a radiopacifying agent, methods of making the polymers, and methods of using the polymers. The imageable particles may comprise a covalently bound compound which chelates the bismuth, for example, through a combination of nitrogen and oxygen atoms.