N-ethyl-N-fluorobutan-2-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-ethyl-N-fluorobutan-2-amine
• 化学式: C₆H₁₄FN
• 分子量: 119.18
• InChiKey: BBDCSXWXHOSZKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS ANTISENS CONJUGUÉS ET LEUR UTILISATION
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2014179620A1

  公开（公告）日：2014-11-06

  Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.

  本文提供了具有共轭基团的寡聚化合物。在某些实施例中，这些寡聚化合物与N-乙酰半乳糖结合。
• [EN] TARGETED THERAPEUTIC NUCLEOSIDES AND THEIR USE<br/>[FR] NUCLÉOSIDES THÉRAPEUTIQUES CIBLÉES ET LEUR UTILISATION
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2015042447A1

  公开（公告）日：2015-03-26

  Provided herein are compounds comprising one or more therapeutic nucleosides and one or more targeting groups. In certain embodiments, the compounds further comprise one or more oligonucleotides. In certain embodiments, a targeting group comprises one or more N-Acetylgalactosamine.

  本文提供的化合物包括一个或多个治疗性核苷和一个或多个靶向基团。在某些实施例中，这些化合物进一步包括一个或多个寡核苷酸。在某些实施例中，一个靶向基团包括一个或多个N-乙酰半乳糖胺。
• US8835669B2
  申请人：——

  公开号：US8835669B2

  公开（公告）日：2014-09-16
• [EN] COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN (a) EXPRESSION<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE MODULATION DE L'EXPRESSION DE L'APOLIPOPROTÉINE (A)
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2014179625A1

  公开（公告）日：2014-11-06

  Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting apo(a) for use in decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) and/or Lp(a). Certain diseases, disorders or conditions related to apo(a) and/or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.
• [EN] COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE MODULATION DE L'EXPRESSION DE L'APOLIPOPROTÉINE C-III
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2014179626A2

  公开（公告）日：2014-11-06

  Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein C-III (ApoClll). In certain embodiments, the ApoClll targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting ApoClll for use in decreasing ApoClll to treat, prevent, or ameliorate diseases, disorders or conditions related to ApoClll. Certain diseases, disorders or conditions related to ApoClll include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.