5-methoxy-2-(dimethylamino)naphthalene | 1439931-83-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-methoxy-2-(dimethylamino)naphthalene
• 英文别名: 5-methoxy-N,N-dimethylnaphthalen-2-amine
• CAS: 1439931-83-5
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: RSYBBUINFSDIJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-氨基-1-萘酚 、 碘甲烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 2.0h， 以0.8 g的产率得到5-甲氧基-2-萘胺
  参考文献：
  名称：

  [EN] CARBOXY X RHODAMINE ANALOGS
  [FR] ANALOGUES DE CARBOXY X RHODAMINE

  摘要：

  本发明提供了新型荧光染料和包含这些染料的试剂盒，可用于标记各种生物分子、细胞和微生物。本发明还提供了利用荧光染料进行研究和开发、法医鉴定、环境研究、诊断、预后和/或治疗疾病状况的各种方法。

  公开号：

  WO2013078244A1

文献信息

• [EN] PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS DE PYRIMIDINE ET COMPOSÉS DE PYRIMIDO INDOLE ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：UNIV HOLY GHOST DUQUESNE

  公开号：WO2016022890A1

  公开（公告）日：2016-02-11

  The present invention discloses substituted pyrimidine and pyrimido indole compounds and optionally pharmaceutically acceptable salts, hydrates or solvates thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt, hydrate, or solvate thereof.

  本发明公开了取代嘧啶和嘧啶并吲哚化合物以及可选择的药用盐、水合物或溶剂化合物。一种治疗患有癌症或疾病的患者的方法包括向患者投予化合物或其药用盐、水合物或溶剂化合物的有效量。
• [EN] MONOCYCLIC, THIENO, PYRIDO, AND PYRROLO PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE OF THE SAME<br/>[FR] COMPOSÉS DE PYRIMIDINES MONOCYCLIQUES, THIÉNOPYRIMIDINES, PYRIDOPYRIMIDINES, ET PYRROLOPYRIMIDINES, LEURS PROCÉDÉS D'UTILISATION ET DE FABRICATION
  申请人：UNIV HOLY GHOST DUQUESNE

  公开号：WO2017031176A1

  公开（公告）日：2017-02-23

  The present invention provides monocyclic, thieno, pyrido and pyrrolo pyrimidine compounds. Pharmaceutical compositions comprising one or more of these compounds and optionally comprising a pharmaceutically acceptable salt or hydrate of one or more of the compounds are provided. Preferably, these pharmaceutical compositions further comprise at least one pharmaceutically acceptable carrier. Methods of treating a patient having cancer are provided wherein a therapeutically effective amount of one or more of these compounds or pharmaceutical compositions are administered to the patient.

  本发明提供了单环、噻吩、吡啶和吡咯基嘧啶化合物。提供了包含这些化合物中的一个或多个的药物组合物，可选地包含一个或多个化合物的药用可接受盐或水合物。优选地，这些药物组合物进一步包含至少一种药用可接受的载体。提供了治疗患有癌症的患者的方法，其中向患者施用了这些化合物或药物组合物中的一个或多个的治疗有效量。
• Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same
  申请人：Duquesne University of the Holy Spirit

  公开号：US10457688B2

  公开（公告）日：2019-10-29

  The present invention provides a compound of Formula XXXI: or a salt or a hydrate of said compound, and further provides a pharmaceutical composition comprising the compound of Formula XXXI and one or more acceptable pharmaceutical carriers. A method of treating a patient having cancer comprising administering a therapeutically effective amount of a compound of Formula XXXI, or a pharmaceutical composition comprising a compound of Formula XXXI and one or more acceptable pharmaceutical carriers to the patient is disclosed.

  本发明提供了一种式 XXXI 的化合物： 或所述化合物的盐或水合物，并进一步提供了包含式XXXI化合物和一种或多种可接受的药物载体的药物组合物。本发明公开了一种治疗癌症患者的方法，该方法包括向患者施用治疗有效量的式XXXI化合物或包含式XXXI化合物和一种或多种可接受的药物载体的药物组合物。
• Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same
  申请人：Duquesne University of the Holy Spirit

  公开号：US20170050978A1

  公开（公告）日：2017-02-23

  The present invention provides a compound of Formula I: wherein R is H, a methyl group, an ethyl group, a n-propyl group, an iso-propyl group, or a n-butyl group; and R 1 is H, a 4′-methyl group, a 4′-OH, a 4′-OMe group, a 2′,3′-C 2 H 4 group, a; 3′,4′-C 2 H 4 group, a 3′,4′-diF, a 3′,4′,5′-triF, or a 4′-OCF 3 ; and optionally including a salt or a hydrate of said compound, and further provides a pharmaceutical composition comprising the compound of Formula I and one or more acceptable pharmaceutical carriers. A method of treating a patient having cancer comprising administering a therapeutically effective amount of a compound of Formula I, or a pharmaceutical composition comprising a compound of Formula I and one or more acceptable pharmaceutical carriers to the patient is disclosed.
• PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE
  申请人：Duquesne University of the Holy Spirit

  公开号：US20170253612A1

  公开（公告）日：2017-09-07

  The present invention discloses a compound comprising the formula: wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the S is replaced by CH 2 , and optionally comprising a pharmaceutically acceptable salt, hydrate, or solvate thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt, hydrate, or solvate thereof.