Calcium;4-[[4-[(2-amino-5-methyl-4-oxo-3,8-dihydropteridin-6-yl)methylamino]benzoyl]amino]-5-hydroxy-5-oxopentanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: Calcium;4-[[4-[(2-amino-5-methyl-4-oxo-3,8-dihydropteridin-6-yl)methylamino]benzoyl]amino]-5-hydroxy-5-oxopentanoate
• 英文别名: calcium;4-[[4-[(2-amino-5-methyl-4-oxo-3,8-dihydropteridin-6-yl)methylamino]benzoyl]amino]-5-hydroxy-5-oxopentanoate
• 化学式: C40H44CaN14O12
• 分子量: 952.9
• InChiKey: DSOWFPARIJWYDF-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.62
• 重原子数：
  67
• 可旋转键数：
  16
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  403
• 氢给体数：
  12
• 氢受体数：
  18

文献信息

• Formulation of amorphous calcium L-5-methyltetrahydrofolate (L-5-MTHF-Ca)
  申请人：Chemo Research, S.L.

  公开号：EP2781214A1

  公开（公告）日：2014-09-24

  The present invention relates to a dosage form which comprises amorphous calcium L-5-methylfolate and cysteine as stabilizing agent and optionally, further auxiliary agents. The dosage forms according to the invention resolves the problem of unstability of amorphous calcium L-5-methylfolate to the oxidation by air.

  本发明涉及一种剂型，它包括无定形的 L-5-甲基叶酸钙和作为稳定剂的半胱氨酸，以及可选的其他辅助剂。 本发明的剂型解决了无定形 L-5- 甲基叶酸钙在空气中氧化不稳定的问题。
• FORMULATION OF AMORPHOUS CALCIUM L-5-METHYLTETRAHYDROFOLATE (L-5-MTHF-Ca)
  申请人：Chemo Research, S.L.

  公开号：EP2976066A1

  公开（公告）日：2016-01-27
• Vitamin Formulations
  申请人：NESTEC S.A.

  公开号：US20160271155A1

  公开（公告）日：2016-09-22

  The present invention provides formulations for enhancing bioavailability of watersoluble compounds including water-soluble vitamins. The formulations include a watersoluble vitamin and a glycoside selected from a diterpene glycoside and a triterpene glycoside. Methods for increasing the bioavailability of a water-soluble vitamin are also described.
• [EN] FORMULATION OF AMORPHOUS CALCIUM L-5-METHYLTETRAHYDROFOLATE (L-5-MTHF-Ca)<br/>[FR] FORMULATION DE L-5-MÉTHYLTÉTRAHYDROFOLATE DE CALCIUM (L-5-MTHF-CA) AMORPHE
  申请人：CHEMO RES S L

  公开号：WO2014146975A1

  公开（公告）日：2014-09-25

  The present invention relates to a dosage form which comprises amorphous calcium L-5-methylfolate and cysteine as stabilizing agent and optionally, further auxiliary agents. The dosage forms according to the invention resolves the problem of instability of amorphous calcium L-5- methylfolate to the oxidation by air.
• [EN] VITAMIN FORMULATIONS<br/>[FR] FORMULATIONS À BASE DE VITAMINES
  申请人：NESTEC SA

  公开号：WO2015077509A1

  公开（公告）日：2015-05-28

  The present invention provides formulations for enhancing bioavailability of watersoluble compounds including water-soluble vitamins. The formulations include a watersoluble vitamin and a glycoside selected from a diterpene glycoside and a triterpene glycoside. Methods for increasing the bioavailability of a water-soluble vitamin are also described.