[(2S)-3-hydroxy-2-octadecanoyloxypropyl] octadecanoate;trimethyl(2-phosphonooxyethyl)azanium

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [(2S)-3-hydroxy-2-octadecanoyloxypropyl] octadecanoate;trimethyl(2-phosphonooxyethyl)azanium
• 化学式: C44H91NO9P+
• 分子量: 809.2
• InChiKey: QRYVDCHRCDZVCB-JFRIYMKVSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  11.76
• 重原子数：
  55
• 可旋转键数：
  42
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Manufacturing of bupivacaine multivesicular liposomes
  申请人：Pacira Pharmaceuticals, Inc.

  公开号：US11357727B1

  公开（公告）日：2022-06-14

  Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

  本申请的实施方案涉及使用独立运行的双切向流过滤模块制造布比卡因多囊脂质体（MVL）的商业制造工艺。
• PROCESS FOR FORMULATING AN ANIONIC AGENT
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：EP2968149A1

  公开（公告）日：2016-01-20
• LOW FRICTION HYDROGELS AND HYDROGEL-CONTAINING COMPOSITE MATERIALS
  申请人：Yeda Research and Development Co., Ltd.

  公开号：EP3016637B1

  公开（公告）日：2020-11-11
• US9629804B2
  申请人：——

  公开号：US9629804B2

  公开（公告）日：2017-04-25
• [EN] PROCESS FOR FORMULATING AN ANIONIC AGENT<br/>[FR] PROCÉDÉ DE FORMULATION D'UN AGENT ANIONIQUE
  申请人：DICERNA PHARMACEUTICALS INC

  公开号：WO2014153163A1

  公开（公告）日：2014-09-25

  Formulations comprising anionic agents such as nucleic acids within a lipid-containing particle methods of formulating a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for preparing a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for therapeutic delivery of an anionic agent to a patient in need thereof, where the anionic agent is formulated in a lipid-containng particle as described herein.