(2R,3S)-3-(4-chlorophenylamino)butan-2-ol | 1342297-69-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2R,3S)-3-(4-chlorophenylamino)butan-2-ol
• 英文别名: (2R,3S)-3-(4-chloroanilino)butan-2-ol
• CAS: 1342297-69-1
• 化学式: C₁₀H₁₄ClNO
• 分子量: 199.68
• InChiKey: WFRPCSYKZBXPHF-JGVFFNPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对氯苯胺 、 2,3-trans-epoxybutane 反应 5.0h， 生成 (2R,3S)-3-(4-chlorophenylamino)butan-2-ol
  参考文献：
  名称：

  Alcaide, Benito; Arjona, Odon; Pradilla, Roberto Fernandez de la, Journal of Chemical Research, Miniprint, 1988, # 3, p. 932 - 957

  摘要：

  DOI：

文献信息

• Aminolytic kinetic resolution of trans epoxides for the simultaneous production of chiral trans β-amino alcohols in the presence of chiral Cr(III) salen complex using an ionic liquid as a green reaction media
  作者：Rukhsana I. Kureshy、Manish Kumar、Santosh Agrawal、Noor-ul H. Khan、Sayed H.R. Abdi、Hari C. Bajaj

  DOI：10.1016/j.tetasy.2010.02.021

  日期：2010.3

  Chiral Cr(III) salen complex 1 having t-Bu substituents at 3,3' and 5,5'-positions was used as a catalyst for the highly enantioselective aminolytic kinetic resolution (AKR) of racemic trans epoxides with different anilines as nucleophile in the presence of different ionic liquids at rt. Excellent yields (>98%) of anti beta-aminoalcohols with high enantioselectivity (ee >99%) was achieved in 4 h when [bmim]PF6 was used as the ionic liquid. The present ionic liquid mediated AKR process is recyclable (up to six cycles with no loss in performance) and is five times quicker than the homogeneous process utilizing conventional organic solvents. (C) 2010 Elsevier Ltd. All rights reserved.
• Alcaide, Benito; Arjona, Odon; Pradilla, Roberto Fernandez de la, Journal of Chemical Research, Miniprint, 1988, # 3, p. 932 - 957
  作者：Alcaide, Benito、Arjona, Odon、Pradilla, Roberto Fernandez de la、Plumet, Joaquin、Rodriguez-Campos, Ignacio M.、Santesmases, Maria J.

  DOI：——

  日期：——