1-Methyl-2-oxo-dihydrochinoxalyl-(3)-brenztraubensaeure | 14152-61-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-Methyl-2-oxo-dihydrochinoxalyl-(3)-brenztraubensaeure
• 英文别名: 2-Oxo-1-methyl-3-<2-oxo-2-carboxy-ethyl>-1,2-dihydro-chinoxalin；3-(4-methyl-3-oxo-3,4-dihydro-quinoxalin-2-yl)-2-oxo-propionic acid；(4-methyl-3-oxo-3,4-dihydro-quinoxalin-2-yl)-pyruvic acid；(4-Methyl-3-oxo-3,4-dihydro-chinoxalin-2-yl)-brenztraubensaeure；Spec-5；3-(4-Methyl-3-oxo-3,4-dihydro-2-quinoxalinyl)-2-oxopropanoic acid；3-(4-methyl-3-oxoquinoxalin-2-yl)-2-oxopropanoic acid
• CAS: 14152-61-5
• 化学式: C₁₂H₁₀N₂O₄
• 分子量: 246.222
• InChiKey: OEOMKZHKJXNVOB-UHFFFAOYSA-N

物化性质

• 熔点：
  218 °C
• 沸点：
  444.3±47.0 °C(Predicted)
• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  87
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,3-二甲基-2-喹噁啉酮 在 氢氧化钾 作用下， 生成 1-Methyl-2-oxo-dihydrochinoxalyl-(3)-brenztraubensaeure
  参考文献：
  名称：

  105.喹喔啉花青。第三部分

  摘要：

  DOI：

  10.1039/jr9430000397

文献信息

• HEME OXYGENASE INHIBITORS, SCREENING METHODS FOR HEME OXYGENASE INHIBITORS AND METHODS OF USE OF HEME OXYGENASE INHIBITORS FOR ANTIMICROBIAL THERAPY
  申请人：Wilks Angela

  公开号：US20100081661A1

  公开（公告）日：2010-04-01

  Inhibitors of microbial heme oxygenase and their use for treatment of microbial infections and bioremediation. The inhibitors of microbial heme oxygenase are useful against a new class of antimicrobial agents to target infections that are persistently difficult to combat with the current spectrum of antimicrobial agents. Screening methods for selecting inhibitors of microbial heme oxygenase.
• INHIBITOR OF HEME DEGRADATION FOR USE TO IMPROVE ANTIBIOTIC TREATMENT OF MYCOBACTERIUM TUBERCULOSIS INFECTION
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Serv

  公开号：US20190201414A1

  公开（公告）日：2019-07-04

  The present invention provides a method of preventing or treating a Mycobacterium tuberculosis (Mtb) infection in a mammal the method comprising administering to the mammal a first inhibitor, wherein the first inhibitor is an inhibitor of heme degradation and wherein the first inhibitor is a metal protoporphyrin, and administering to the mammal a second inhibitor, wherein the second inhibitor is an inhibitor of Mtb, wherein administration of the first and second inhibitors to the mammal prevents or treats Mtb infection in the mammal.
• US8450368B2
  申请人：——

  公开号：US8450368B2

  公开（公告）日：2013-05-28
• 105. Quinoxaline cyanines. Part III
  作者：A. H. Cook、R. F. Naylor

  DOI：10.1039/jr9430000397

  日期：——