3-[2]naphthyl-3-oxo-2-phenyl-propionaldehyde | 109689-34-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3-[2]naphthyl-3-oxo-2-phenyl-propionaldehyde
• 英文别名: 3-Naphthalen-2-yl-3-oxo-2-phenylpropanal
• CAS: 109689-34-1
• 化学式: C₁₉H₁₄O₂
• 分子量: 274.319
• InChiKey: ULNORXSWFSNVTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(萘-2-基)-2-苯基乙酮 、 甲酸乙酯 在 sodium ethanolate 作用下， 生成 3-[2]naphthyl-3-oxo-2-phenyl-propionaldehyde
  参考文献：
  名称：

  Takagi; Yasuda, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1959, vol. 79, p. 467,469

  摘要：

  DOI：

文献信息

• Metal chelates and methods of using them for time-resolved fluorescence
  申请人：——

  公开号：US20040082768A1

  公开（公告）日：2004-04-29

  &bgr;-diketone fluorescent tags are disclosed, particularly those enabling the use of excitation energy in the near visible or visible spectrum. In some cases, these tags allow the use of cost-effective excitation devices such as LED's. The compounds form fluorescent chelates (complexes) with lanthanide (III) rare earth metal ions (such as Eu3+). The fluorescent complex may be included in a latex microparticle, such as a styrene latex particle. Ideally, the complex has an absorption maximum &lgr; equal to or greater than 360 nm, and the compound is characterized by a pKa<9.0. Kits and methods for detecting target molecules (e.g. immunoassays) are also disclosed. Such methods and kits typically use a ligand for binding to the target molecule and a labeling agent attached to the ligand. The fluorescent complexes described above are at least part of the labeling agent. Apparatus for detecting fluorescence from a sample includes an irradiating energy source that produces irradiating energy &lgr; equal to or greater than 360 nm; a detector positioned to detect fluorescence from the sample; and a sample holder for holding the sample in position to be irradiated by the energy source. A light-emitting diode is preferably used as the irradiating energy source.

  本文披露了-b二酮荧光标记物，特别是那些能够利用近可见光谱或可见光谱中的激发能量的标记物。在某些情况下，这些标记物允许使用LED等成本效益的激发装置。这些化合物与镧系(III)稀土金属离子（如Eu3+）形成荧光螯合物（复合物）。荧光复合物可以包含在乳胶微粒中，如苯乙烯乳胶微粒。理想情况下，复合物具有吸收峰值λ等于或大于360纳米，化合物的pKa<9.0。还披露了用于检测目标分子（例如免疫分析）的试剂盒和方法。这些方法和试剂盒通常使用配体与目标分子结合以及连接到配体的标记剂。上述荧光复合物至少是标记剂的一部分。用于检测样品中荧光的装置包括产生波长λ等于或大于360纳米的辐射能源的辐射能源；放置在样品上以检测来自样品的荧光的探测器；以及用于保持样品处于能源照射位置的样品支架。最好使用发光二极管作为辐射能源。
• US7053249B2
  申请人：——

  公开号：US7053249B2

  公开（公告）日：2006-05-30