benzyl 1-(4-(2,3-dioxo-3,4-dihydroquinoxalin-1(2H)-yl)piperidin-1-yl)cyclooctanecarboxylate | 1040363-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: benzyl 1-(4-(2,3-dioxo-3,4-dihydroquinoxalin-1(2H)-yl)piperidin-1-yl)cyclooctanecarboxylate
• 英文别名: benzyl 1-(4-(2,3-dihydro-2,3-dioxoquinoxalin-4(1H)-yl)piperidin-1-yl)cyclooctanecarboxylate；benzyl 1-[4-(2,3-dioxo-4H-quinoxalin-1-yl)piperidin-1-yl]cyclooctane-1-carboxylate
• CAS: 1040363-31-2
• 化学式: C₂₉H₃₅N₃O₄
• 分子量: 489.615
• InChiKey: SYJHDYQSWVYDKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  79
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  benzyl 1-(4-(N-(2-(tert-butoxycarbonylamino)phenyl)-2-methoxy-2-oxoacetamido)piperidin-1-yl)cyclooctanecarboxylate 在 盐酸 、 碳酸氢钠 作用下， 以 乙酸乙酯 、 水 为溶剂， 反应 1.0h， 以76%的产率得到benzyl 1-(4-(2,3-dioxo-3,4-dihydroquinoxalin-1(2H)-yl)piperidin-1-yl)cyclooctanecarboxylate
  参考文献：
  名称：

  WO2008/89201

  摘要：

  公开号：

文献信息

• HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF
  申请人：Brown Kevin C.

  公开号：US20100022519A1

  公开（公告）日：2010-01-28

  The invention relates to Heterocyclic-Substituted Piperidine Compounds, compositions comprising an effective amount of a Heterocyclic-Substituted Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Heterocyclic-Substituted Piperidine Compound.

  本发明涉及杂环取代哌啶化合物，包括含有有效量的杂环取代哌啶化合物的组合物和治疗或预防疾病的方法，例如疼痛，通过向需要治疗的动物施用有效量的杂环取代哌啶化合物。
• Substituted-Quinoxaline-Type Piperidine Compounds and the Uses Thereof
  申请人：FUCHINO Kouki

  公开号：US20100216726A1

  公开（公告）日：2010-08-26

  The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.

  本发明涉及取代喹喔啉型哌啶化合物、包含有效量取代喹喔啉型哌啶化合物的组合物以及治疗或预防某种疾病（如疼痛）的方法，包括向需要治疗的动物施用有效量取代喹喔啉型哌啶化合物。
• SUBSTITUTED-QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND THE USES THEREOF
  申请人：Purdue Pharma L.P.

  公开号：US20150141643A1

  公开（公告）日：2015-05-21

  The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.

  该发明涉及取代喹喔啉型哌啶化合物，包括一种有效量的取代喹喔啉型哌啶化合物的组合物以及治疗或预防疾病的方法，例如疼痛，通过向需要治疗的动物施用一种有效量的取代喹喔啉型哌啶化合物。
• Heterocyclic-substituted piperidines as ORL-1 ligands
  申请人：Purdue Pharma L.P.

  公开号：EP2280008A2

  公开（公告）日：2011-02-02

  The invention relates to Heterocyclic-Substituted Piperidine Compounds, compositions comprising an effective amount of a Heterocyclic-Substituted Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Heterocyclic-Substituted Piperidine Compound.

  本发明涉及杂环取代的哌啶化合物、包含有效量杂环取代的哌啶化合物的组合物，以及治疗或预防疼痛等疾病的方法，包括向有需要的动物施用有效量的杂环取代的哌啶化合物。
• Heterocyclic-substituted piperidine compounds and the uses thereof
  申请人：Purdue Pharma LP

  公开号：EP2397477A1

  公开（公告）日：2011-12-21

  The invention relates to Heterocyclic-Substituted Piperidine Compounds, compositions comprising an effective amount of a Heterocyclic-Substituted Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Heterocyclic-Substituted Piperidine Compound.

  本发明涉及杂环取代的哌啶化合物、包含有效量杂环取代的哌啶化合物的组合物，以及治疗或预防疼痛等疾病的方法，包括向有需要的动物施用有效量的杂环取代的哌啶化合物。