(2E)-4-chloro-3-oxo-2-(4-oxo-1H-quinazolin-2-ylidene)butanenitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (2E)-4-chloro-3-oxo-2-(4-oxo-1H-quinazolin-2-ylidene)butanenitrile
• 化学式: C₁₂H₈ClN₃O₂
• mdl: MFCD07343867
• 分子量: 261.66
• InChiKey: SOEASRUCSGGRTM-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  82
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED QUINAZOLINONE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES<br/>[FR] COMPOSÉS DE QUINAZOLINONE SUBSTITUÉS POUR LE TRAITEMENT DE MALADIES PROLIFÉRATIVES
  申请人：BAYER PHARMA AG

  公开号：WO2017162510A1

  公开（公告）日：2017-09-28

  The present invention relates to substituted quinazolinone compounds of general formula (I) : in which R1, R2, R3, R4, R5, R6, R7, and R8 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.