N'-[(1R,2S,4S,5'S,6S,7S,8R,9S,12S,13S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-piperidine]-16-yl]hexane-1,6-diamine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: N'-[(1R,2S,4S,5'S,6S,7S,8R,9S,12S,13S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-piperidine]-16-yl]hexane-1,6-diamine
• 化学式: C₃₃H₅₉N₃O
• 分子量: 513.8
• InChiKey: ZVQRZLFGCVCHTP-FAGLOGLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  59.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] ATP SYNTHASE INHIBITORS AND STEROID ALKALOIDS AND USES THEREOF AS ANTIMICROBIAL AGENTS AND AS POTENTIATORS FOR AMINOGLYCOSIDES AGAINST PATHOGENIC BACTERIA<br/>[FR] INHIBITEURS D'ATP SYNTHASE ET ALCALOÏDES STÉROÏDIENS ET LEURS UTILISATIONS EN TANT QU'AGENTS ANTIMICROBIENS ET POTENTIATEURS D'AMINOGLYCOSIDES CONTRE DES BACTÉRIES PATHOGÈNES
  申请人：SOCPRA SCIENCES ET GÉNIE S E C

  公开号：WO2015095971A1

  公开（公告）日：2015-07-02

  The present invention provides bacterial ATP synthase inhibitors such as a compound of formula (I): (Formula (I)) (A) in combination with an aminoglycoside antibiotic for preventing or treating a bacterial infection in a subject; or (B) (a) for preventing or treating an infection caused by an electron transport-deficient bacteria in a subject; or (b) for the disinfection, sterilization and/or antisepsis of an object contaminated with an electron transport-deficient bacteria. There are provided compositions and kits using such compounds and inhibitors.

  本发明提供细菌ATP合酶抑制剂，例如式(I)的化合物：(A)与氨基糖苷类抗生素结合，用于预防或治疗受试者的细菌感染；或(B) (a) 用于预防或治疗受试者体内由电子传递缺陷细菌引起的感染；或(b) 用于对受电子传递缺陷细菌污染的物体进行消毒、灭菌和/或防腐。提供了使用这些化合物和抑制剂的组合物和工具包。
• Steroid alkaloids and compositions and kits thereof
  申请人：SOCPRA SCIENCES ET GÉNIE S.E.C.

  公开号：US10716797B2

  公开（公告）日：2020-07-21

  The present invention provides bacterial ATP synthase inhibitors such as a compound of formula (I): There are provided compositions and kits using such compounds and inhibitors.

  本发明提供细菌 ATP 合酶抑制剂，如式 (I) 化合物： 还提供了使用此类化合物和抑制剂的组合物和试剂盒。
• ATP SYNTHASE INHIBITORS AND STEROID ALKALOIDS AND USES THEREOF AS ANTIMICROBIAL AGENTS AND AS POTENTIATORS FOR AMINOGLYCOSIDES AGAINST PATHOGENIC BACTERIA
  申请人：SOCPRA SCIENCES ET GÉNIE S.E.C.

  公开号：US20160317556A1

  公开（公告）日：2016-11-03

  The present invention provides bacterial ATP synthase inhibitors such as a compound of formula (I): (Formula (I)) (A) in combination with an aminoglycoside antibiotic for preventing or treating a bacterial infection in a subject; or (B) (a) for preventing or treating an infection caused by an electron transport-deficient bacteria in a subject; or (b) for the disinfection, sterilization and/or antisepsis of an object contaminated with an electron transport-deficient bacteria. There are provided compositions and kits using such compounds and inhibitors.