N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N'-[3-piperidin-1-yl-4-(trifluoromethyl)benzyl]urea | 710954-91-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N'-[3-piperidin-1-yl-4-(trifluoromethyl)benzyl]urea
• 英文别名: N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N'-[3-piperidin-1-yl-4-(tri-fluoromethyl)benzyl]urea；1-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-[[3-piperidin-1-yl-4-(trifluoromethyl)phenyl]methyl]urea
• CAS: 710954-91-9
• 化学式: C₂₄H₂₈F₃N₃O₂
• 分子量: 447.5
• InChiKey: ITDCQZCTLNZNTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  64.6
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  8-氨基-3,4-二氢萘-1(2H)-酮 在 吡啶 、 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 甲醇 、 二甲基亚砜 为溶剂， 反应 3.0h， 生成 N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N'-[3-piperidin-1-yl-4-(trifluoromethyl)benzyl]urea
  参考文献：
  名称：

  [EN] TETRAHYDRO-NAPHTHALENE DERIVATIVES AS VANILLOID RECEPTOR ANTAGONISTS
  [FR] DERIVES TETRAHYDRO-NAPHTALENE SERVANT D'ANTAGONISTES DU RECEPTEUR VANILLOIDE

  摘要：

  该发明涉及四氢萘衍生物及其盐，作为药物制剂的活性成分。本发明的四氢萘衍生物作为VR1拮抗剂具有出色的活性，并且适用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿失禁、急迫性尿失禁、过度活动膀胱、慢性疼痛、神经病性疼痛、术后疼痛、类风湿性关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风、炎症性疾病、哮喘和慢性阻塞性肺疾病的治疗。

  公开号：

  WO2004052845A1

文献信息

• Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists
  申请人：Tajimi Masaomi

  公开号：US20060135505A1

  公开（公告）日：2006-06-22

  This invention relates to tetrahydro-naphthalene derivatives of formula (I) in which the variable groups are as defined in the specification and claims, and tautomeric and stereoisomeric forms and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonists and are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD. The compounds, pharmaceutical compositions containing them, and methods of treatment using them are disclosed and claimed.

  本发明涉及公式（I）的四氢萘衍生物，其中变量基在说明书和权利要求书中定义，并且其互变异构体和立体异构体以及盐，它们可用作制药制剂的活性成分。本发明的四氢萘衍生物具有优异的VR1拮抗剂活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿失禁，强迫性尿失禁，过度活动的膀胱，慢性疼痛，神经病性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，疼痛，神经损伤，缺血，神经退行性疾病，中风，炎症性疾病，哮喘和COPD。本文披露和声称了这些化合物，含有它们的制药组合物以及使用它们的治疗方法。
• Tetrahydro-Naphthalene Derivatives as Vanilloid Receptor Antagonists
  申请人：Tajimi Masaomi

  公开号：US20090209514A1

  公开（公告）日：2009-08-20

  This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydronaphthalene derivatives of the present invention have an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.

  本发明涉及四氢萘衍生物及其盐，其作为药物制剂的活性成分是有用的。本发明的四氢萘衍生物具有优异的VR1拮抗剂活性，适用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿失禁、急迫性尿失禁、过度活跃的膀胱、慢性疼痛、神经痛、术后疼痛、类风湿性关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风、炎症性疾病、哮喘和COPD。
• TETRAHYDRO-NAPHTHALENE DERIVATIVES AS VANILLOID RECEPTOR ANTAGONISTS
  申请人：Xention Limited

  公开号：EP1572632B1

  公开（公告）日：2008-08-13
• US7544716B2
  申请人：——

  公开号：US7544716B2

  公开（公告）日：2009-06-09
• [EN] TETRAHYDRO-NAPHTHALENE DERIVATIVES AS VANILLOID RECEPTOR ANTAGONISTS<br/>[FR] DERIVES TETRAHYDRO-NAPHTALENE SERVANT D'ANTAGONISTES DU RECEPTEUR VANILLOIDE
  申请人：BAYER HEALTHCARE AG

  公开号：WO2004052845A1

  公开（公告）日：2004-06-24

  This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.

  该发明涉及四氢萘衍生物及其盐，作为药物制剂的活性成分。本发明的四氢萘衍生物作为VR1拮抗剂具有出色的活性，并且适用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿失禁、急迫性尿失禁、过度活动膀胱、慢性疼痛、神经病性疼痛、术后疼痛、类风湿性关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风、炎症性疾病、哮喘和慢性阻塞性肺疾病的治疗。