Cambridge id 6274084

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Cambridge id 6274084
• 英文别名: 3-(3-methylphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
• 化学式: C₂₂H₁₇N₃O
• 分子量: 339.4
• InChiKey: UDXOKVRGXFJGFJ-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Arf6 inhibitors and methods of synthesis and use thereof
  申请人：Navigen, Inc.

  公开号：US10849901B2

  公开（公告）日：2020-12-01

  Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.

  本文公开了抑制 Arf6 的化合物和方法。本文还公开了用 Arf6 抑制剂治疗受试者的药物组合物和方法。
• Small Molecular Inhibitors of RAD51 Recombinase and Methods Thereof
  申请人：Mazin Alexander V.

  公开号：US20140080849A1

  公开（公告）日：2014-03-20

  The invention includes compositions comprising a selective small-molecule inhibitor of RAD51 recombinase and a pharmaceutically acceptable carrier. The invention further includes methods of treating or preventing cancer in a subject, comprising the step of administering to the subject the compositions contemplated within the invention.
• SMALL MOLECULAR INHIBITORS OF RAD51 RECOMBINASE AND METHODS THEREOF
  申请人：Mazin Alexander V.

  公开号：US20160106751A1

  公开（公告）日：2016-04-21

  The invention includes compositions comprising a selective small-molecule inhibitor of RAD51 recombinase and a pharmaceutically acceptable carrier. The invention further includes methods of treating or preventing cancer in a subject, comprising the step of administering to the subject the compositions contemplated within the invention.
• ARF6 INHIBITORS AND METHODS OF SYNTHESIS AND USE THEREOF
  申请人：Navigen, Inc.

  公开号：US20170189405A1

  公开（公告）日：2017-07-06

  Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.
• US9216177B2
  申请人：——

  公开号：US9216177B2

  公开（公告）日：2015-12-22