[p-(benzyloxy)benzyl] acrylic acid | 129673-20-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: [p-(benzyloxy)benzyl] acrylic acid
• 英文别名: 2-[(4-Phenylmethoxyphenyl)methyl]prop-2-enoic acid
• CAS: 129673-20-7
• 化学式: C₁₇H₁₆O₃
• 分子量: 268.312
• InChiKey: HOEFMWYZDBURIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [p-(benzyloxy)benzyl] acrylic acid 在 TEA 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成 (S)-2-[2-Acetylsulfanylmethyl-3-(4-benzyloxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionic acid ethyl ester
  参考文献：
  名称：

  Thiol inhibitors of endothelin-converting enzyme

  摘要：

  Synthesis and structure activity relationships of a series of thiol inhibitors of the endothelin-converting enzyme (ECE) are presented. Optimisation of the stereochemistry as well as of the P'(1) and P'(2) residues led to inhibitors with similar potency to that of phosphoramidon. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00420-9
• 作为产物：
  描述：

  methyl 3-(4-(phenylmethoxy) phenyl)-alpha-[(dimethylamino)methyl]-propanoate 在 sodium hydroxide 作用下， 以 异丙醇 为溶剂， 反应 2.0h， 生成 [p-(benzyloxy)benzyl] acrylic acid
  参考文献：
  名称：

  Thiol inhibitors of endothelin-converting enzyme

  摘要：

  Synthesis and structure activity relationships of a series of thiol inhibitors of the endothelin-converting enzyme (ECE) are presented. Optimisation of the stereochemistry as well as of the P'(1) and P'(2) residues led to inhibitors with similar potency to that of phosphoramidon. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00420-9

文献信息

• Aminobenzoic and aminocyclohexane-carboylic acid compounds, compositions, and their method of use
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0361365A1

  公开（公告）日：1990-04-04

  Compounds of the formula wherein X is inhibit the action of neutral endopeptidase. As a result, such compounds produce diuresis, natriuresis, and lower blood pressure as well as being useful in the treatment of congestive heart failure, relieving pain, and diarrhea when administered to a mammalian host.

  其中X的化合物抑制中性内肽酶的作用。因此，这些化合物产生利尿、排钠和降低血压的效果，同时在治疗充血性心力衰竭、缓解疼痛和腹泻时对哺乳动物宿主有用。
• NOUVEAUX DERIVES SOUFRES COMPORTANT UNE LIAISON AMIDE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS ET LES COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT
  申请人：Aventis Pharma S.A.

  公开号：EP0888341B1

  公开（公告）日：2005-11-30
• Thiol inhibitors of endothelin-converting enzyme
  作者：Pierre Deprez、Jacques Guillaume、Jacques Dumas、Jean-Paul Vevert

  DOI：10.1016/0960-894x(96)00420-9

  日期：1996.10

  Synthesis and structure activity relationships of a series of thiol inhibitors of the endothelin-converting enzyme (ECE) are presented. Optimisation of the stereochemistry as well as of the P'(1) and P'(2) residues led to inhibitors with similar potency to that of phosphoramidon. Copyright (C) 1996 Elsevier Science Ltd