3-(3-Dimethylamino-phenyl)-propionsaeure-aethylester | 7116-45-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(3-Dimethylamino-phenyl)-propionsaeure-aethylester
• 英文别名: ethyl 3-dimethylaminobenzenepropanoate；ethyl 3-[3-(dimethylamino)phenyl]propanoate
• CAS: 7116-45-2
• 化学式: C₁₃H₁₉NO₂
• 分子量: 221.299
• InChiKey: UGPACPFRSAFSLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(3-Dimethylamino-phenyl)-propionsaeure-aethylester 以36%的产率得到
  参考文献：
  名称：

  CARSON, JOHN R.

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(M-氨基苯基)丙酸乙酯 以72%的产率得到
  参考文献：
  名称：

  CARSON, JOHN R.

  摘要：

  DOI：

文献信息

• New Preparation and Reactions of Arylaluminum Reagents Using Barbier Conditions
  作者：Paul Knochel、Hongjun Gao

  DOI：10.1055/s-0028-1088127

  日期：——

  The reaction of various aryl bromides with magnesium turnings, LiCl and R2AlCl (R = Et, i-Bu) provides at room temperature arylaluminum reagents in high yields. These organometallic species undergo readily 1,4-additions, acylations, allylations, and Pd-catalyzed cross-couplings with various aryl iodides and bromides.

  多种芳基溴与镁屑、LiCl和R2AlCl（R = Et，i-Bu）在室温下反应，可高产率地得到芳基铝试剂。这些有机金属物种容易发生1,4-加成、酰化、烯丙基化以及与多种芳基碘和溴在钯催化下的交叉偶联反应。
• Methods for the treatment of hypertension
  申请人：McNeilab, Inc.

  公开号：US04898889A1

  公开（公告）日：1990-02-06

  Acetylene compounds of the formula (I): ##STR1## wherein Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The compounds possess antihypertensive and anti-anginal properties and may be used in the treatment of humans. Methods for the preparation and use of such acetylene compounds are also disclosed.

  公开了化学式（I）的乙炔化合物：##STR1##其中Y、R.sub.1、R.sub.2、R.sub.3和R.sub.4如本文所述，m为0-3，n为0-2，Ar为苯或芳香杂环。这些化合物具有降压和抗心绞痛的特性，可用于人类的治疗。还公开了制备和使用这种乙炔化合物的方法。
• Methods for the treatment of angina
  申请人：McNeilab, Inc.

  公开号：US04960798A1

  公开（公告）日：1990-10-02

  Acetylene compounds of the formula (I): ##STR1## wherein Y, R.sub.1, R.sub.2 R.sub.3, and R.sub.4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The compounds possess anti-hypertensive and anti-anginal properties and may be used in the treatment of humans. Methods for the preparation and use of such acetylene compounds are also disclosed.

  公开了式子（I）的乙炔化合物：##STR1## 其中Y，R.sub.1，R.sub.2，R.sub.3和R.sub.4如此描述，m为0-3，n为0-2，Ar为苯基或芳香杂环。这些化合物具有抗高血压和抗心绞痛特性，可用于人类的治疗。还公开了制备和使用这种乙炔化合物的方法。
• Acetylene derivatives for the treatment of hypertension and angina
  申请人：McNeilab, Inc.

  公开号：EP0145361A2

  公开（公告）日：1985-06-19

  57 Acetylene compounds of the formula (I): wherein Y, R1, R,, R3, and R4 are as described herein, m is 0-3, n is 0-2 and Ar is pehnyl or an aromatic heterocycle are disclosed. The compounds possess antihypertensive and anti-anginal properties and may be used in the treatment of humans. Methods for the preparation and use of such acetylene compounds are also disclosed.

  57 本发明公开了式 (I) 的乙炔化合物：其中 Y、R1、R、R3 和 R4 如本文所述，m 为 0-3，n 为 0-2，Ar 为正烷基或芳香杂环。 这些化合物具有抗高血压和抗心绞痛的特性，可用于人类治疗。 本发明还公开了制备和使用此类乙炔化合物的方法。
• CARSON, JOHN R.
  作者：CARSON, JOHN R.

  DOI：——

  日期：——