1,4-di[(2-hydroxy-3-quinoxalinyl)hydrazino]phthalazine | 1309384-81-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,4-di[(2-hydroxy-3-quinoxalinyl)hydrazino]phthalazine
• 英文别名: 3-[2-[4-[2-(3-oxo-4H-quinoxalin-2-yl)hydrazinyl]phthalazin-1-yl]hydrazinyl]-1H-quinoxalin-2-one
• CAS: 1309384-81-3
• 化学式: C₂₄H₁₈N₁₀O₂
• 分子量: 478.473
• InChiKey: NWLDRJMBWVXQPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  157
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  在 盐酸 、 水 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以63%的产率得到1,4-di[(2-hydroxy-3-quinoxalinyl)hydrazino]phthalazine
  参考文献：
  名称：

  Exploration on structure and anticonvulsant activity of transition metal complexes derived from an “end-off” compartmental bis-quinoxaline derivative with phthalazinyl-diazine as endogenous bridge

  摘要：

  An oligoquinoxaline derivative with phthalazine core has been prepared by condensation of 1,4-dihydrazinophthalazine with 2,3-dichloroquinoxaline in dry ethanol followed by acid hydrolysis. Classical endogenous bridging of phthalazine core with its diazine fragment was established in the transition metal(II) complexes derived from the ligand system by using various physicochemical and spectral techniques. The organic host acts as a hexadentate chelate with N4O2 donating sites for coordination towards later first-row transition metal ions. Complexes are in good agreement with the octahedral geometry and found to be 1:1 electrolytes. All synthesized compounds were screened for anticonvulsant activity in Wistar rats by using maximal electroshock method. The ligand, and Co(II) and Ni(II) complexes show appreciable suppression towards electroshock-induced seizures.

  DOI：

  10.1007/s00706-011-0462-1

文献信息

• Exploration on structure and anticonvulsant activity of transition metal complexes derived from an “end-off” compartmental bis-quinoxaline derivative with phthalazinyl-diazine as endogenous bridge
  作者：Srinivasa Budagumpi、Naveen V. Kulkarni、M. P. Sathisha、Sandeep P. Netalkar、Vidyanand K. Revankar、D. K. Suresh

  DOI：10.1007/s00706-011-0462-1

  日期：2011.5

  An oligoquinoxaline derivative with phthalazine core has been prepared by condensation of 1,4-dihydrazinophthalazine with 2,3-dichloroquinoxaline in dry ethanol followed by acid hydrolysis. Classical endogenous bridging of phthalazine core with its diazine fragment was established in the transition metal(II) complexes derived from the ligand system by using various physicochemical and spectral techniques. The organic host acts as a hexadentate chelate with N4O2 donating sites for coordination towards later first-row transition metal ions. Complexes are in good agreement with the octahedral geometry and found to be 1:1 electrolytes. All synthesized compounds were screened for anticonvulsant activity in Wistar rats by using maximal electroshock method. The ligand, and Co(II) and Ni(II) complexes show appreciable suppression towards electroshock-induced seizures.