(S)-3-Hydroxy-4-(5-hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-butyric acid | 160162-39-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-3-Hydroxy-4-(5-hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-butyric acid
• 英文别名: Juglomycin Z；(3S)-3-hydroxy-4-(5-hydroxy-3-methyl-1,4-dioxonaphthalen-2-yl)butanoic acid
• CAS: 160162-39-0
• 化学式: C₁₅H₁₄O₆
• 分子量: 290.273
• InChiKey: MIJQQLCPVSCPSU-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 (S)-3-Hydroxy-4-(5-hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-butyric acid 以 乙醚 为溶剂， 反应 0.17h， 以76.3%的产率得到juglomycin Z-methyl ester
  参考文献：
  名称：

  Biosynthetic capacities of actinomycetes. 2. Juglomycin Z, a new naphthoquinone antibiotic from Streptomyces tendae.

  摘要：

  A new juglomycin-type antibiotic was identified by a HPLC-diode array screening technique in the culture filtrate of Streptomyces tendae Tü 901/8c. Juglomycin Z (1) differs from all other known juglomycin compounds by an additional methyl group in position 3 of the naphthoquinone ring system. Juglomycin Z is antibiotically active against Gram-positive and Gram-negative bacteria and against yeasts.

  DOI：

  10.7164/antibiotics.47.1116

文献信息

• Biosynthetic capacities of actinomycetes. 2. Juglomycin Z, a new naphthoquinone antibiotic from Streptomyces tendae.
  作者：HANS-PETER FIEDLER、ANDREAS KULIK、TRAUGOTT C. SCHÜZ、CORINNA VOLKMANN、AXEL ZEECK

  DOI：10.7164/antibiotics.47.1116

  日期：——

  A new juglomycin-type antibiotic was identified by a HPLC-diode array screening technique in the culture filtrate of Streptomyces tendae Tü 901/8c. Juglomycin Z (1) differs from all other known juglomycin compounds by an additional methyl group in position 3 of the naphthoquinone ring system. Juglomycin Z is antibiotically active against Gram-positive and Gram-negative bacteria and against yeasts.